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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL259
Target Type SINGLE PROTEIN
Preferred Name Melanocortin receptor 4
Synonyms MC4-R | MC4R | Melanocortin receptor 4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > short peptide receptor (family a gpcr) > melanocortin receptor

Target Components

Component Description Relationship Accession
Melanocortin receptor 4 SINGLE PROTEIN P32245

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111423 Melanocortin receptor (M1 and M4) SELECTIVITY GROUP
CHEMBL2111397 Melanocortin receptor (M4 and M5) SELECTIVITY GROUP
CHEMBL2111323 Melanocortin receptor (M3 and M4) SELECTIVITY GROUP

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2070241 BREMELANOTIDE Melanocortin receptor 4 agonist 3 PubMed PubMed
CHEMBL3301624 SETMELANOTIDE Melanocortin receptor 4 agonist 3 PubMed PubMed
CHEMBL1090488 PF-00446687 Melanocortin receptor 4 agonist 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000166603
Ensembl ENSG00000166603
GO Cellular Component GO:0005634 (nucleus)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004977 (melanocortin receptor activity)
GO:0004980 (melanocyte-stimulating hormone receptor activity)
GO:0005515 (protein binding)
GO:0017046 (peptide hormone binding)
GO:0031625 (ubiquitin protein ligase binding)
GO:0042923 (neuropeptide binding)
GO Biological Process GO:0002024 (diet induced thermogenesis)
GO:0006112 (energy reserve metabolic process)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007188 (adenylate cyclase-modulating G-protein coupled receptor signaling pathway)
GO:0007189 (adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:0007631 (feeding behavior)
GO:0019222 (regulation of metabolic process)
GO:0030073 (insulin secretion)
GO:0032868 (response to insulin)
GO:0045780 (positive regulation of bone resorption)
GO:0060259 (regulation of feeding behavior)
GO:2000252 (negative regulation of feeding behavior)
GO:2000821 (regulation of grooming behavior)
Wikipedia Melanocortin_4_receptor

Target Cross References - Protein

canSAR P32245
CGD Obesity, autosomal dominant
Human Protein Atlas ENSG00000166603
IntAct P32245
Guide to Pharmacology 285
Open Targets ENSG00000166603
PharmGKB PA30676
Pharos P32245 (Tchem)
Reactome R-HSA-375276 (Peptide ligand-binding receptors.)
R-HSA-418555 (G alpha (s) signalling events.)
UniProt B2RAC3 P32245 Q16317 Q3MIJ6

Target Cross References - Domain

InterPro IPR000155 (Mcort_rcpt_4.)
IPR000276 (GPCR_Rhodpsn.)
IPR001671 (Melcrt_ACTH_rcpt.)
IPR001908 (Melancort_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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