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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2585
Target Type SINGLE PROTEIN
Preferred Name Neuronal acetylcholine receptor protein alpha-9 subunit
Synonyms Acra9 | Chrna9 | NACHR alpha-9 | Neuronal acetylcholine receptor subunit alpha-9 | Nicotinic acetylcholine receptor subunit alpha-9
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > nicotinic acetylcholine receptor > nicotinic acetylcholine receptor alpha subunit

Target Components

Component Description Relationship Accession
Neuronal acetylcholine receptor subunit alpha-9 SINGLE PROTEIN P43144

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3038462 Nicotinic acetylcholine receptor alpha9/alpha10 PROTEIN COMPLEX
CHEMBL2094110 Neuronal acetylcholine receptor PROTEIN COMPLEX GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005892 (acetylcholine-gated channel complex)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO Molecular Function GO:0004889 (acetylcholine-activated cation-selective channel activity)
GO:0005216 (ion channel activity)
GO:0005230 (extracellular ligand-gated ion channel activity)
GO:0005262 (calcium channel activity)
GO:0015464 (acetylcholine receptor activity)
GO:0022848 (acetylcholine-gated cation channel activity)
GO:0042166 (acetylcholine binding)
GO Biological Process GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0006812 (cation transport)
GO:0006816 (calcium ion transport)
GO:0007165 (signal transduction)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007271 (synaptic transmission, cholinergic)
GO:0007605 (sensory perception of sound)
GO:0042472 (inner ear morphogenesis)
GO:0050910 (detection of mechanical stimulus involved in sensory perception of sound)
GO:0070588 (calcium ion transmembrane transport)
GO:0098655 (cation transmembrane transport)
GO:0099565 (chemical synaptic transmission, postsynaptic)

Target Cross References - Protein

canSAR P43144
Reactome R-RNO-629594 (Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.)
UniProt P43144 Q6PW49

Target Cross References - Domain

InterPro IPR002394 (Nicotinic_acetylcholine_rcpt.)
IPR006029 (Neurotrans-gated_channel_TM.)
IPR006201 (Neur_channel.)
IPR006202 (Neur_chan_lig-bd.)
IPR018000 (Neurotransmitter_ion_chnl_CS.)
IPR027361 (Acetylcholine_rcpt_TM.)
Pfam PF02931 (Neur_chan_LBD)
PF02932 (Neur_chan_memb)
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