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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2584
Target Type SINGLE PROTEIN
Preferred Name Neuronal acetylcholine receptor protein alpha-2 subunit
Synonyms Acra2 | Chrna2 | Neuronal acetylcholine receptor subunit alpha-2
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > nicotinic acetylcholine receptor > nicotinic acetylcholine receptor alpha subunit

Target Components

Component Description Relationship Accession
Neuronal acetylcholine receptor subunit alpha-2 SINGLE PROTEIN P12389

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094110 Neuronal acetylcholine receptor PROTEIN COMPLEX GROUP
CHEMBL1907590 Neuronal acetylcholine receptor; alpha2/beta4 PROTEIN COMPLEX
CHEMBL1907592 Neuronal acetylcholine receptor; alpha2/beta2 PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005886 (plasma membrane)
GO:0005892 (acetylcholine-gated channel complex)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO:0071944 (cell periphery)
GO Molecular Function GO:0004889 (acetylcholine-activated cation-selective channel activity)
GO:0005216 (ion channel activity)
GO:0005230 (extracellular ligand-gated ion channel activity)
GO:0008144 (drug binding)
GO:0015464 (acetylcholine receptor activity)
GO:0042166 (acetylcholine binding)
GO Biological Process GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0007165 (signal transduction)
GO:0007271 (synaptic transmission, cholinergic)
GO:0007274 (neuromuscular synaptic transmission)
GO:0035094 (response to nicotine)
GO:0051291 (protein heterooligomerization)
GO:0098655 (cation transmembrane transport)
GO:0099565 (chemical synaptic transmission, postsynaptic)

Target Cross References - Protein

canSAR P12389
Guide to Pharmacology 463
Reactome R-RNO-629594 (Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.)
R-RNO-629597 (Highly calcium permeable nicotinic acetylcholine receptors.)
UniProt O08952 P12389 Q53YK3

Target Cross References - Domain

InterPro IPR002394 (Nicotinic_acetylcholine_rcpt.)
IPR006029 (Neurotrans-gated_channel_TM.)
IPR006201 (Neur_channel.)
IPR006202 (Neur_chan_lig-bd.)
IPR018000 (Neurotransmitter_ion_chnl_CS.)
IPR027361 (Acetylcholine_rcpt_TM.)
Pfam PF02931 (Neur_chan_LBD)
PF02932 (Neur_chan_memb)
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