ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL2579
Target Type SINGLE PROTEIN
Preferred Name GABA receptor alpha-6 subunit
Synonyms GABA(A) receptor subunit alpha-6 | GABRA6 | Gamma-aminobutyric acid receptor subunit alpha-6
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > gaba-a receptor

Target Components

Component Description Relationship Accession
Gamma-aminobutyric acid receptor subunit alpha-6 SINGLE PROTEIN Q16445

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2093872 GABA-A receptor; anion channel PROTEIN COMPLEX GROUP
CHEMBL2111370 GABA A receptor alpha-6/beta-2/gamma-2 PROTEIN COMPLEX
CHEMBL3885578 Gamma-aminobutyric acid receptor subunit alpha-6/beta-3 PROTEIN COMPLEX
CHEMBL2095190 GABA-A receptor; alpha-6/beta-3/gamma-2 PROTEIN COMPLEX
CHEMBL2109244 GABA-A receptor; agonist GABA site PROTEIN COMPLEX GROUP
CHEMBL2109243 GABA-A receptor; benzodiazepine site PROTEIN COMPLEX GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000145863
Ensembl ENSG00000145863
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0034707 (chloride channel complex)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO:1902711 (GABA-A receptor complex)
GO Molecular Function GO:0004888 (transmembrane signaling receptor activity)
GO:0004890 (GABA-A receptor activity)
GO:0005216 (ion channel activity)
GO:0005230 (extracellular ligand-gated ion channel activity)
GO:0005254 (chloride channel activity)
GO:0008503 (benzodiazepine receptor activity)
GO Biological Process GO:0006811 (ion transport)
GO:0006821 (chloride transport)
GO:0007165 (signal transduction)
GO:0007214 (gamma-aminobutyric acid signaling pathway)
GO:0034220 (ion transmembrane transport)
GO:1902476 (chloride transmembrane transport)
Wikipedia GABRA6

Target Cross References - Protein

canSAR Q16445
Human Protein Atlas ENSG00000145863
IntAct Q16445
Guide to Pharmacology 409
Open Targets ENSG00000145863
PharmGKB PA28494
Pharos Q16445 (Tclin)
Reactome R-HSA-112314 (Neurotransmitter receptors and postsynaptic signal transmission.)
R-HSA-977441 (GABA A receptor activation.)
UniProt A8K096 Q16445 Q4VAV2

Target Cross References - Domain

InterPro IPR001390 (GABAAa_rcpt.)
IPR005436 (GABBAa6_rcpt.)
IPR006028 (GABAA/Glycine_rcpt.)
IPR006029 (Neurotrans-gated_channel_TM.)
IPR006201 (Neur_channel.)
IPR006202 (Neur_chan_lig-bd.)
IPR018000 (Neurotransmitter_ion_chnl_CS.)
IPR036719 (Neuro-gated_channel_TM_sf.)
IPR036734 (Neur_chan_lig-bd_sf.)
Pfam PF02931 (Neur_chan_LBD)
PF02932 (Neur_chan_memb)
spacer
spacer