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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2574
Target Type SINGLE PROTEIN
Preferred Name Dopamine D4 receptor
Synonyms D(2C) dopamine receptor | D(4) dopamine receptor | Dopamine D4 receptor | Drd4
Organism Mus musculus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > dopamine receptor

Target Components

Component Description Relationship Accession
D(4) dopamine receptor SINGLE PROTEIN P51436

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111359 Dopamine receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005938 (cell cortex)
GO:0012506 (vesicle membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0043025 (neuronal cell body)
GO:0043195 (terminal bouton)
GO:0043197 (dendritic spine)
GO:0043679 (axon terminus)
GO Molecular Function GO:0001591 (dopamine neurotransmitter receptor activity, coupled via Gi/Go)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004952 (dopamine neurotransmitter receptor activity)
GO:0008144 (drug binding)
GO:0017124 (SH3 domain binding)
GO:0035240 (dopamine binding)
GO:0042802 (identical protein binding)
GO:0046872 (metal ion binding)
GO:0051379 (epinephrine binding)
GO:0051380 (norepinephrine binding)
GO Biological Process GO:0000187 (activation of MAPK activity)
GO:0001662 (behavioral fear response)
GO:0001963 (synaptic transmission, dopaminergic)
GO:0001975 (response to amphetamine)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007195 (adenylate cyclase-inhibiting dopamine receptor signaling pathway)
GO:0007212 (dopamine receptor signaling pathway)
GO:0007614 (short-term memory)
GO:0008306 (associative learning)
GO:0008344 (adult locomotory behavior)
GO:0008355 (olfactory learning)
GO:0032417 (positive regulation of sodium:proton antiporter activity)
GO:0033674 (positive regulation of kinase activity)
GO:0034776 (response to histamine)
GO:0042053 (regulation of dopamine metabolic process)
GO:0042596 (fear response)
GO:0042752 (regulation of circadian rhythm)
GO:0046928 (regulation of neurotransmitter secretion)
GO:0048148 (behavioral response to cocaine)
GO:0048511 (rhythmic process)
GO:0050482 (arachidonic acid secretion)
GO:0050709 (negative regulation of protein secretion)
GO:0050804 (modulation of synaptic transmission)
GO:0050848 (regulation of calcium-mediated signaling)
GO:0060080 (inhibitory postsynaptic potential)
GO:0060406 (positive regulation of penile erection)
GO:1901386 (negative regulation of voltage-gated calcium channel activity)
GO:2000463 (positive regulation of excitatory postsynaptic potential)

Target Cross References - Protein

canSAR P51436
IntAct P51436
MICAD NBK23025 (Dopamine D4 receptors)
Reactome R-MMU-390651 (Dopamine receptors.)
R-MMU-418594 (G alpha (i) signalling events.)
UniProt O35838 P51436 Q7TT80 Q8BXS4

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000929 (Dopamine_rcpt.)
IPR002185 (Dopamine_D4_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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