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Target Report Card

Target Name and Classification

Target ID CHEMBL257
Preferred Name Angiotensin II type 2 (AT-2) receptor
Synonyms AT2 | Agtr2 | Angiotensin II type-2 receptor | Type-2 angiotensin II receptor
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > short peptide receptor (family a gpcr) > angiotensin receptor

Target Components

Component Description Relationship Accession
Type-2 angiotensin II receptor SINGLE PROTEIN P35351

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094112 Angiotensin II receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0001965 (G-protein alpha-subunit binding)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004945 (angiotensin type II receptor activity)
GO:0005515 (protein binding)
GO:0008134 (transcription factor binding)
GO:0017046 (peptide hormone binding)
GO Biological Process GO:0001822 (kidney development)
GO:0001991 (regulation of systemic arterial blood pressure by circulatory renin-angiotensin)
GO:0002018 (renin-angiotensin regulation of aldosterone production)
GO:0002033 (vasodilation by angiotensin involved in regulation of systemic arterial blood pressure)
GO:0002035 (brain renin-angiotensin system)
GO:0006883 (cellular sodium ion homeostasis)
GO:0006954 (inflammatory response)
GO:0007165 (signal transduction)
GO:0007166 (cell surface receptor signaling pathway)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007199 (G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger)
GO:0008284 (positive regulation of cell proliferation)
GO:0010243 (response to organonitrogen compound)
GO:0010459 (negative regulation of heart rate)
GO:0010700 (negative regulation of norepinephrine secretion)
GO:0021695 (cerebellar cortex development)
GO:0030182 (neuron differentiation)
GO:0032304 (negative regulation of icosanoid secretion)
GO:0032516 (positive regulation of phosphoprotein phosphatase activity)
GO:0035556 (intracellular signal transduction)
GO:0035566 (regulation of metanephros size)
GO:0035640 (exploration behavior)
GO:0035815 (positive regulation of renal sodium excretion)
GO:0035932 (aldosterone secretion)
GO:0038166 (angiotensin-activated signaling pathway)
GO:0042306 (regulation of protein import into nucleus)
GO:0042311 (vasodilation)
GO:0042416 (dopamine biosynthetic process)
GO:0042981 (regulation of apoptotic process)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0048147 (negative regulation of fibroblast proliferation)
GO:0050715 (positive regulation of cytokine secretion)
GO:0051000 (positive regulation of nitric-oxide synthase activity)
GO:0051387 (negative regulation of neurotrophin TRK receptor signaling pathway)
GO:0060993 (kidney morphogenesis)
GO:0061049 (cell growth involved in cardiac muscle cell development)
GO:0071549 (cellular response to dexamethasone stimulus)
GO:0072300 (positive regulation of metanephric glomerulus development)
GO:0090190 (positive regulation of branching involved in ureteric bud morphogenesis)
GO:0097746 (regulation of blood vessel diameter)
GO:0097755 (positive regulation of blood vessel diameter)
GO:2001238 (positive regulation of extrinsic apoptotic signaling pathway)

Target Cross References - Protein

canSAR P35351
Guide to Pharmacology 35
Reactome R-RNO-375276 (Peptide ligand-binding receptors.)
R-RNO-418594 (G alpha (i) signalling events.)
UniProt P35351

Target Cross References - Domain

InterPro IPR000147 (ATII_AT2_rcpt.)
IPR000248 (ATII_rcpt.)
IPR000276 (GPCR_Rhodpsn.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)