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Target Report Card

Target Name and Classification

Target ID CHEMBL255
Preferred Name Adenosine A2b receptor
Synonyms ADORA2B | Adenosine receptor A2b
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > nucleotide-like receptor (family a gpcr) > adenosine receptor

Target Components

Component Description Relationship Accession
Adenosine receptor A2b SINGLE PROTEIN P29275

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111329 Adenosine receptor PROTEIN FAMILY
CHEMBL2096679 Adenosine receptors; A1 & A2 SELECTIVITY GROUP
CHEMBL2095234 Adenosine receptors; A2b & A3 SELECTIVITY GROUP
CHEMBL2094257 Adenosine A2 receptor PROTEIN FAMILY
CHEMBL2096908 Adenosine receptors; A1 & A2b SELECTIVITY GROUP

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL260933 GS 6201 Adenosine A2b receptor antagonist 1 PubMed PubMed
CHEMBL1672627 LAS101057 Adenosine A2b receptor antagonist 1 PubMed PubMed
CHEMBL3545204 QAF805 Adenosine A2b receptor antagonist 1 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000170425
Ensembl ENSG00000170425
GO Cellular Component GO:0005622 (intracellular)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0001609 (G-protein coupled adenosine receptor activity)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO Biological Process GO:0000187 (activation of MAPK activity)
GO:0001973 (adenosine receptor signaling pathway)
GO:0002882 (positive regulation of chronic inflammatory response to non-antigenic stimulus)
GO:0006968 (cellular defense response)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007189 (adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:0007190 (activation of adenylate cyclase activity)
GO:0007254 (JNK cascade)
GO:0007588 (excretion)
GO:0010575 (positive regulation of vascular endothelial growth factor production)
GO:0030828 (positive regulation of cGMP biosynthetic process)
GO:0031284 (positive regulation of guanylate cyclase activity)
GO:0031668 (cellular response to extracellular stimulus)
GO:0032722 (positive regulation of chemokine production)
GO:0032755 (positive regulation of interleukin-6 production)
GO:0043306 (positive regulation of mast cell degranulation)
GO:0044267 (cellular protein metabolic process)
GO:0060087 (relaxation of vascular smooth muscle)
Wikipedia Adenosine_A2B_receptor

Target Cross References - Protein

canSAR P29275
Human Protein Atlas ENSG00000170425
IntAct P29275
Guide to Pharmacology 20
Open Targets ENSG00000170425
PharmGKB PA24585
Pharos P29275 (Tclin)
Reactome R-HSA-417973 (Adenosine P1 receptors.)
R-HSA-418555 (G alpha (s) signalling events.)
R-HSA-5683826 (Surfactant metabolism.)
UniProt P29275

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR001435 (Adeno_A2B_rcpt.)
IPR001634 (Adenosn_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)