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Target Report Card

Target Name and Classification

Target ID CHEMBL2544
Preferred Name Peptidyl-glycine alpha-amidating monooxygenase
Synonyms PAL | PAM | PAM | PHM | Peptidyl-alpha-hydroxyglycine alpha-amidating lyase | Peptidyl-glycine alpha-amidating monooxygenase | Peptidylamidoglycolate lyase | Peptidylglycine alpha-hydroxylating monooxygenase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Peptidyl-glycine alpha-amidating monooxygenase SINGLE PROTEIN P19021

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000145730
Ensembl ENSG00000145730
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005802 (trans-Golgi network)
GO:0005886 (plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030141 (secretory granule)
GO:0030667 (secretory granule membrane)
GO:0043005 (neuron projection)
GO:0043025 (neuronal cell body)
GO:0043204 (perikaryon)
GO:0048471 (perinuclear region of cytoplasm)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0003824 (catalytic activity)
GO:0004497 (monooxygenase activity)
GO:0004504 (peptidylglycine monooxygenase activity)
GO:0004598 (peptidylamidoglycolate lyase activity)
GO:0005507 (copper ion binding)
GO:0005509 (calcium ion binding)
GO:0005515 (protein binding)
GO:0008270 (zinc ion binding)
GO:0016491 (oxidoreductase activity)
GO:0016715 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen)
GO:0016829 (lyase activity)
GO:0019901 (protein kinase binding)
GO:0031418 (L-ascorbic acid binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001519 (peptide amidation)
GO:0001666 (response to hypoxia)
GO:0001676 (long-chain fatty acid metabolic process)
GO:0006357 (regulation of transcription from RNA polymerase II promoter)
GO:0006518 (peptide metabolic process)
GO:0007417 (central nervous system development)
GO:0007507 (heart development)
GO:0007595 (lactation)
GO:0008152 (metabolic process)
GO:0009268 (response to pH)
GO:0009404 (toxin metabolic process)
GO:0018032 (protein amidation)
GO:0019538 (protein metabolic process)
GO:0022602 (ovulation cycle process)
GO:0032355 (response to estradiol)
GO:0032956 (regulation of actin cytoskeleton organization)
GO:0042476 (odontogenesis)
GO:0042493 (response to drug)
GO:0046688 (response to copper ion)
GO:0050708 (regulation of protein secretion)
GO:0051260 (protein homooligomerization)
GO:0051384 (response to glucocorticoid)
GO:0055114 (oxidation-reduction process)
GO:0060135 (maternal process involved in female pregnancy)
GO:0060173 (limb development)
Wikipedia Peptidylglycine_alpha-amidating_monooxygenase

Target Cross References - Protein

canSAR P19021
Human Protein Atlas ENSG00000145730
IntAct P19021
Open Targets ENSG00000145730
PharmGKB PA32926
UniProt A6NMR0 A8K293 O43211 O95080 P19021 Q16252 Q16253 Q54A45 Q86U53 Q8WVC7 Q9UCG0

Target Cross References - Domain

InterPro IPR000323 (Cu2_ascorb_mOase_N.)
IPR000720 (PHM/PAL.)
IPR001258 (NHL_repeat.)
IPR008977 (PHM/PNGase_F_dom_sf.)
IPR011042 (6-blade_b-propeller_TolB-like.)
IPR013017 (NHL_repeat_subgr.)
IPR014783 (Cu2_ascorb_mOase_CS-2.)
IPR014784 (Cu2_ascorb_mOase-like_C.)
IPR020611 (Cu2_ascorb_mOase_CS-1.)
IPR024548 (Cu2_monoox_C.)
IPR036939 (Cu2_ascorb_mOase_N_sf.)
Pfam PF01082 (Cu2_monooxygen)
PF01436 (NHL)
PF03712 (Cu2_monoox_C)