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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL254
Target Type SINGLE PROTEIN
Preferred Name Phosphodiesterase 4A
Synonyms DPDE2 | DPDE2 | PDE46 | PDE4A | cAMP-specific 3',5'-cyclic phosphodiesterase 4A
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > phosphodiesterase > phosphodiesterase 4 > phosphodiesterase 4a

Target Components

Component Description Relationship Accession
cAMP-specific 3',5'-cyclic phosphodiesterase 4A SINGLE PROTEIN P27815

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363066 3',5'-cyclic phosphodiesterase PROTEIN FAMILY
CHEMBL2095153 Phosphodiesterase; PDE3 & PDE4 SELECTIVITY GROUP
CHEMBL2093863 Phosphodiesterase 4 PROTEIN FAMILY
CHEMBL2111340 Phosphodiesterase 4 and 5 (PDE4 and PDE5) SELECTIVITY GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000065989
Ensembl ENSG00000065989
GO Cellular Component GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0032587 (ruffle membrane)
GO:0042995 (cell projection)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0004114 (3',5'-cyclic-nucleotide phosphodiesterase activity)
GO:0004115 (3',5'-cyclic-AMP phosphodiesterase activity)
GO:0005515 (protein binding)
GO:0008081 (phosphoric diester hydrolase activity)
GO:0016787 (hydrolase activity)
GO:0030552 (cAMP binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006198 (cAMP catabolic process)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007608 (sensory perception of smell)
GO:0010738 (regulation of protein kinase A signaling)
GO:0035690 (cellular response to drug)
GO:0043949 (regulation of cAMP-mediated signaling)
Wikipedia PDE4A

Target Cross References - Protein

canSAR P27815
Human Protein Atlas ENSG00000065989
IntAct P27815
Guide to Pharmacology 1300
Open Targets ENSG00000065989
PharmGKB PA33128
Reactome R-HSA-180024 (DARPP-32 events.)
R-HSA-418555 (G alpha (s) signalling events.)
UniProt O75522 O76092 P27815 Q16255 Q16691 Q5DM53 Q6PMT2 Q8IVA7 Q8WUQ3 Q9H3H2

Target Cross References - Domain

InterPro IPR002073 (PDEase_catalytic_dom.)
IPR003607 (HD/PDEase_dom.)
IPR023088 (PDEase.)
IPR023174 (PDEase_CS.)
IPR036971 (PDEase_catalytic_dom_sf.)
Pfam PF00233 (PDEase_I)

Target Cross References - Structure

PDBe 2QYK 3I8V 3TVX
CREDO 2QYK 3I8V 3TVX
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