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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2528
Target Type SINGLE PROTEIN
Preferred Name Butyrylcholinesterase
Synonyms Acylcholine acylhydrolase | Bche | Butyrylcholine esterase | Choline esterase II | Cholinesterase | Pseudocholinesterase
Organism Mus musculus
Species Group No
Protein Target Classification
  • enzyme > hydrolase

Target Components

Component Description Relationship Accession
Cholinesterase SINGLE PROTEIN Q03311

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005641 (nuclear envelope lumen)
GO:0005783 (endoplasmic reticulum)
GO:0005788 (endoplasmic reticulum lumen)
GO:0016020 (membrane)
GO Molecular Function GO:0003990 (acetylcholinesterase activity)
GO:0004104 (cholinesterase activity)
GO:0016787 (hydrolase activity)
GO:0033265 (choline binding)
GO:0042802 (identical protein binding)
GO:0052689 (carboxylic ester hydrolase activity)
GO Biological Process GO:0007584 (response to nutrient)
GO:0007612 (learning)
GO:0008285 (negative regulation of cell proliferation)
GO:0014016 (neuroblast differentiation)
GO:0019695 (choline metabolic process)
GO:0042493 (response to drug)
GO:0043279 (response to alkaloid)
GO:0050805 (negative regulation of synaptic transmission)
GO:0051384 (response to glucocorticoid)
GO:0051593 (response to folic acid)

Target Cross References - Protein

MICAD NBK23388 (Butyrylcholinesterase (BChE, BuChE))
NBK23441 (Butyrylcholinesterase)
Reactome R-MMU-112311 (Neurotransmitter clearance.)
R-MMU-1483191 (Synthesis of PC.)
R-MMU-422085 (Synthesis, secretion, and deacylation of Ghrelin.)
UniProt Q03311 Q543J3

Target Cross References - Domain

InterPro IPR000997 (Cholinesterase.)
IPR002018 (CarbesteraseB.)
IPR014788 (AChE_tetra.)
IPR019819 (Carboxylesterase_B_CS.)
IPR019826 (Carboxylesterase_B_AS.)
IPR029058 (AB_hydrolase.)
Pfam PF00135 (COesterase)
PF08674 (AChE_tetra)
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