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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2525
Target Type SINGLE PROTEIN
Preferred Name Beta secretase 2
Synonyms AEPLC | ALP56 | ASP1 | ASP21 | Asp 1 | Aspartic-like protease 56 kDa | Aspartyl protease 1 | BACE2 | Beta-secretase 2 | Beta-site APP cleaving enzyme 2 | Beta-site amyloid precursor protein cleaving enzyme 2 | DRAP | Down region aspartic protease | Memapsin-1 | Membrane-associated aspartic protease 1 | Theta-secretase | UNQ418/PRO852
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > aspartic protease > aspartic protease aa clan > aspartic protease a1a subfamily

Target Components

Component Description Relationship Accession
Beta-secretase 2 SINGLE PROTEIN Q9Y5Z0

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111390 Beta-secretase (BACE) PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000182240
Ensembl ENSG00000182240
GO Cellular Component GO:0005768 (endosome)
GO:0005783 (endoplasmic reticulum)
GO:0005794 (Golgi apparatus)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0001540 (beta-amyloid binding)
GO:0004190 (aspartic-type endopeptidase activity)
GO:0008233 (peptidase activity)
GO:0016787 (hydrolase activity)
GO Biological Process GO:0006508 (proteolysis)
GO:0006509 (membrane protein ectodomain proteolysis)
GO:0016486 (peptide hormone processing)
GO:0030163 (protein catabolic process)
GO:0042985 (negative regulation of amyloid precursor protein biosynthetic process)
GO:0050435 (beta-amyloid metabolic process)
Wikipedia Beta-secretase_2

Target Cross References - Protein

canSAR Q9Y5Z0
Human Protein Atlas ENSG00000182240
IntAct Q9Y5Z0
Guide to Pharmacology 2331
Open Targets ENSG00000182240
PharmGKB PA25233
UniProt A8K7P1 Q5DIH8 Q8N2D4 Q9H2V8 Q9NZL1 Q9NZL2 Q9UJT6 Q9Y5Z0

Target Cross References - Domain

InterPro IPR001461 (Aspartic_peptidase_A1.)
IPR001969 (Aspartic_peptidase_AS.)
IPR009119 (BACE.)
IPR009121 (BACE2.)
IPR021109 (Peptidase_aspartic_dom.)
IPR033121 (PEPTIDASE_A1.)
Pfam PF00026 (Asp)

Target Cross References - Structure

PDBe 2EWY 3ZKG 3ZKI 3ZKM 3ZKN 3ZKQ 3ZKS 3ZKX 3ZL7 3ZLQ 4BEL 4BFB
CREDO 2EWY 3ZKG 3ZKI 3ZKM 3ZKN 3ZKQ 3ZKS 3ZKX 3ZL7 3ZLQ 4BEL 4BFB
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