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Target Report Card

Target Name and Classification

Target ID CHEMBL2506
Target Type SINGLE PROTEIN
Preferred Name PI3-kinase p85-alpha subunit
Synonyms GRB1 | PI3-kinase regulatory subunit alpha | PI3-kinase subunit p85-alpha | PI3K regulatory subunit alpha | PIK3R1 | Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha | Phosphatidylinositol 3-kinase regulatory subunit alpha | PtdIns-3-kinase regulatory subunit alpha | PtdIns-3-kinase regulatory subunit p85-alpha
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Phosphatidylinositol 3-kinase regulatory subunit alpha SINGLE PROTEIN P27986

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3038510 PI3K p110 beta/p85 alpha PROTEIN COMPLEX
CHEMBL3559703 PI3-kinase class I PROTEIN COMPLEX GROUP
CHEMBL2111367 PI3-kinase p110-alpha/p85-alpha PROTEIN COMPLEX
CHEMBL2111432 PI3-kinase p110-delta/p85-alpha PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000145675
Ensembl ENSG00000145675
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005801 (cis-Golgi network)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005911 (cell-cell junction)
GO:0005942 (phosphatidylinositol 3-kinase complex)
GO:0005943 (phosphatidylinositol 3-kinase complex, class IA)
GO:0016020 (membrane)
GO:0032991 (macromolecular complex)
GO:1990578 (perinuclear endoplasmic reticulum membrane)
GO Molecular Function GO:0001784 (phosphotyrosine binding)
GO:0005068 (transmembrane receptor protein tyrosine kinase adaptor activity)
GO:0005158 (insulin receptor binding)
GO:0005159 (insulin-like growth factor receptor binding)
GO:0005168 (neurotrophin TRKA receptor binding)
GO:0005515 (protein binding)
GO:0008134 (transcription factor binding)
GO:0016303 (1-phosphatidylinositol-3-kinase activity)
GO:0019903 (protein phosphatase binding)
GO:0035014 (phosphatidylinositol 3-kinase regulator activity)
GO:0036312 (phosphatidylinositol 3-kinase regulatory subunit binding)
GO:0043125 (ErbB-3 class receptor binding)
GO:0043548 (phosphatidylinositol 3-kinase binding)
GO:0043559 (insulin binding)
GO:0043560 (insulin receptor substrate binding)
GO:0046934 (phosphatidylinositol-4,5-bisphosphate 3-kinase activity)
GO:0046935 (1-phosphatidylinositol-3-kinase regulator activity)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0001678 (cellular glucose homeostasis)
GO:0001953 (negative regulation of cell-matrix adhesion)
GO:0006468 (protein phosphorylation)
GO:0006606 (protein import into nucleus)
GO:0006661 (phosphatidylinositol biosynthetic process)
GO:0007162 (negative regulation of cell adhesion)
GO:0007165 (signal transduction)
GO:0007173 (epidermal growth factor receptor signaling pathway)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007411 (axon guidance)
GO:0008286 (insulin receptor signaling pathway)
GO:0008625 (extrinsic apoptotic signaling pathway via death domain receptors)
GO:0008630 (intrinsic apoptotic signaling pathway in response to DNA damage)
GO:0014065 (phosphatidylinositol 3-kinase signaling)
GO:0015031 (protein transport)
GO:0016032 (viral process)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0030168 (platelet activation)
GO:0030183 (B cell differentiation)
GO:0030335 (positive regulation of cell migration)
GO:0031295 (T cell costimulation)
GO:0032760 (positive regulation of tumor necrosis factor production)
GO:0032869 (cellular response to insulin stimulus)
GO:0033120 (positive regulation of RNA splicing)
GO:0034644 (cellular response to UV)
GO:0034976 (response to endoplasmic reticulum stress)
GO:0036092 (phosphatidylinositol-3-phosphate biosynthetic process)
GO:0038095 (Fc-epsilon receptor signaling pathway)
GO:0038096 (Fc-gamma receptor signaling pathway involved in phagocytosis)
GO:0038128 (ERBB2 signaling pathway)
GO:0042307 (positive regulation of protein import into nucleus)
GO:0043066 (negative regulation of apoptotic process)
GO:0043551 (regulation of phosphatidylinositol 3-kinase activity)
GO:0045671 (negative regulation of osteoclast differentiation)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046326 (positive regulation of glucose import)
GO:0046626 (regulation of insulin receptor signaling pathway)
GO:0046854 (phosphatidylinositol phosphorylation)
GO:0048009 (insulin-like growth factor receptor signaling pathway)
GO:0048010 (vascular endothelial growth factor receptor signaling pathway)
GO:0048015 (phosphatidylinositol-mediated signaling)
GO:0050821 (protein stabilization)
GO:0050852 (T cell receptor signaling pathway)
GO:0050900 (leukocyte migration)
GO:0051492 (regulation of stress fiber assembly)
GO:0051897 (positive regulation of protein kinase B signaling)
GO:0060396 (growth hormone receptor signaling pathway)
GO:1900103 (positive regulation of endoplasmic reticulum unfolded protein response)
GO:1903076 (regulation of protein localization to plasma membrane)
GO:1903078 (positive regulation of protein localization to plasma membrane)
GO:2001275 (positive regulation of glucose import in response to insulin stimulus)
Wikipedia PIK3R1

Target Cross References - Protein

canSAR P27986
CGD Agammaglobulinemia 7, autosomal recessive
Human Protein Atlas ENSG00000145675
IntAct P27986
Open Targets ENSG00000145675
PharmGKB PA33312
Pharos P27986 (Tchem)
Reactome R-HSA-109704 (PI3K Cascade.)
R-HSA-114604 (GPVI-mediated activation cascade.)
R-HSA-1236382 (Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants.)
R-HSA-1250342 (PI3K events in ERBB4 signaling.)
R-HSA-1257604 (PIP3 activates AKT signaling.)
R-HSA-1266695 (Interleukin-7 signaling.)
R-HSA-1433557 (Signaling by SCF-KIT.)
R-HSA-1660499 (Synthesis of PIPs at the plasma membrane.)
R-HSA-180292 (GAB1 signalosome.)
R-HSA-1839117 (Signaling by cytosolic FGFR1 fusion mutants.)
R-HSA-186763 (Downstream signal transduction.)
R-HSA-1963642 (PI3K events in ERBB2 signaling.)
R-HSA-198203 (PI3K/AKT activation.)
R-HSA-202424 (Downstream TCR signaling.)
R-HSA-2029485 (Role of phospholipids in phagocytosis.)
R-HSA-210993 (Tie2 Signaling.)
R-HSA-2219530 (Constitutive Signaling by Aberrant PI3K in Cancer.)
R-HSA-2424491 (DAP12 signaling.)
R-HSA-2730905 (Role of LAT2/NTAL/LAB on calcium mobilization.)
R-HSA-373753 (Nephrin family interactions.)
R-HSA-388841 (Costimulation by the CD28 family.)
R-HSA-389357 (CD28 dependent PI3K/Akt signaling.)
R-HSA-392451 (G beta:gamma signalling through PI3Kgamma.)
R-HSA-416476 (G alpha (q) signalling events.)
R-HSA-416482 (G alpha (12/13) signalling events.)
R-HSA-430116 (GP1b-IX-V activation signalling.)
R-HSA-4420097 (VEGFA-VEGFR2 Pathway.)
R-HSA-512988 (Interleukin-3, 5 and GM-CSF signaling.)
R-HSA-5637810 (Constitutive Signaling by EGFRvIII.)
R-HSA-5654689 (PI-3K cascade:FGFR1.)
R-HSA-5654695 (PI-3K cascade:FGFR2.)
R-HSA-5654710 (PI-3K cascade:FGFR3.)
R-HSA-5654720 (PI-3K cascade:FGFR4.)
R-HSA-5655253 (Signaling by FGFR2 in disease.)
R-HSA-5655291 (Signaling by FGFR4 in disease.)
R-HSA-5655302 (Signaling by FGFR1 in disease.)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
R-HSA-6811558 (PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.)
R-HSA-8851907 (MET activates PI3K/AKT signaling.)
R-HSA-8853334 (Signaling by FGFR3 fusions in cancer.)
R-HSA-8853338 (Signaling by FGFR3 point mutants in cancer.)
R-HSA-8853659 (RET signaling.)
R-HSA-912526 (Interleukin receptor SHC signaling.)
R-HSA-912631 (Regulation of signaling by CBL.)
R-HSA-983695 (Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.)
UniProt B3KT19 D3DWA0 E7EX19 P27986 Q15747 Q4VBZ7 Q53EM6 Q8IXA2 Q8N1C5

Target Cross References - Domain

InterPro IPR000198 (RhoGAP_dom.)
IPR000980 (SH2.)
IPR001452 (SH3_domain.)
IPR001720 (PI3kinase_P85_p55.)
IPR008936 (Rho_GTPase_activation_prot.)
IPR032498 (PI3K_P85_iSH2.)
IPR035020 (PI3kinase_P85_cSH2.)
IPR035022 (PI3kinase_P85_nSH2.)
IPR035591 (PI3K_p85alpha_SH3.)
IPR036028 (SH3-like_dom_sf.)
IPR036860 (SH2_dom_sf.)
Pfam PF00017 (SH2)
PF00620 (RhoGAP)
PF16454 (PI3K_P85_iSH2)

Target Cross References - Structure

PDBe 1H9O 1PBW 1PHT 2IUG 2IUH 2IUI 2RD0 2V1Y 3HHM 3HIZ 3I5R 3I5S 4A55 4JPS 4L1B 4L23 4L2Y 4OVU 4OVV 4WAF 4YKN 4ZOP 5AUL 5FI4 More...
CREDO 1H9O 1PBW 1PHT 2IUG 2IUH 2IUI 2RD0 2V1Y 3HHM 3HIZ 3I5R 3I5S 4A55 4JPS 4L1B 4L23 4L2Y 4OVU 4OVV 4WAF 4YKN 4ZOP 5AUL 5FI4 More...
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