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Target Report Card

Target Name and Classification

Target ID CHEMBL2494
Preferred Name CaM kinase IV
Synonyms CAMK | CAMK-GR | CAMK4 | CAMKIV | CaM kinase-GR | CaMK IV | Calcium/calmodulin-dependent protein kinase type IV
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > camk protein kinase group > camk protein kinase camk1 family

Target Components

Component Description Relationship Accession
Calcium/calmodulin-dependent protein kinase type IV SINGLE PROTEIN Q16566

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000152495
Ensembl ENSG00000152495
GO Cellular Component GO:0001650 (fibrillar center)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004683 (calmodulin-dependent protein kinase activity)
GO:0005516 (calmodulin binding)
GO:0005524 (ATP binding)
GO:0009931 (calcium-dependent protein serine/threonine kinase activity)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0002250 (adaptive immune response)
GO:0002372 (myeloid dendritic cell cytokine production)
GO:0002376 (immune system process)
GO:0006468 (protein phosphorylation)
GO:0006954 (inflammatory response)
GO:0007165 (signal transduction)
GO:0007616 (long-term memory)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0033081 (regulation of T cell differentiation in thymus)
GO:0035556 (intracellular signal transduction)
GO:0043011 (myeloid dendritic cell differentiation)
GO:0045670 (regulation of osteoclast differentiation)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0046777 (protein autophosphorylation)
Wikipedia CAMK4

Target Cross References - Protein

canSAR Q16566
Human Protein Atlas ENSG00000152495
IntAct Q16566
Guide to Pharmacology 1955
Open Targets ENSG00000152495
PharmGKB PA26050
Pharos Q16566 (Tbio)
Reactome R-HSA-111932 (CaMK IV-mediated phosphorylation of CREB.)
R-HSA-2151201 (Transcriptional activation of mitochondrial biogenesis.)
R-HSA-442717 (CREB phosphorylation through the activation of CaMKK.)
R-HSA-442745 (Activation of CaMK IV.)
UniProt D3DSZ7 Q16566

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure