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Target Report Card

Target Name and Classification

Target ID CHEMBL2492
Target Type SINGLE PROTEIN
Preferred Name Neuronal acetylcholine receptor protein alpha-7 subunit
Synonyms CHRNA7 | NACHRA7 | Neuronal acetylcholine receptor subunit alpha-7
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > nicotinic acetylcholine receptor > nicotinic acetylcholine receptor alpha subunit

Target Components

Component Description Relationship Accession
Neuronal acetylcholine receptor subunit alpha-7 SINGLE PROTEIN P36544

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2151572 ENCENICLINE Neuronal acetylcholine receptor protein alpha-7 subunit partial agonist 3 PubMed PubMed
CHEMBL559478 SSR180711 Neuronal acetylcholine receptor protein alpha-7 subunit partial agonist 2 PubMed PubMed
CHEMBL1258006 BRADANICLINE Neuronal acetylcholine receptor protein alpha-7 subunit agonist 2 PubMed PubMed
CHEMBL2151437 AZD0328 Neuronal acetylcholine receptor protein alpha-7 subunit agonist 2 PubMed PubMed
CHEMBL3544952 RG3487 Neuronal acetylcholine receptor protein alpha-7 subunit partial agonist 2 PubMed PubMed PubMed
CHEMBL3545231 ABT-126 Neuronal acetylcholine receptor protein alpha-7 subunit agonist 2 DOI PubMed
CHEMBL3545232 AQW051 Neuronal acetylcholine receptor protein alpha-7 subunit partial agonist 2 PubMed PubMed
CHEMBL3545291 JNJ-39393406 Neuronal acetylcholine receptor protein alpha-7 subunit positive allosteric modulator 2 PubMed PubMed
CHEMBL3545410 TC-6987 Neuronal acetylcholine receptor protein alpha-7 subunit agonist 2 Other PubMed
CHEMBL3707249 ASM-024 Neuronal acetylcholine receptor protein alpha-7 subunit modulator 2 Other PubMed PubMed
CHEMBL3707316 ND0801 Neuronal acetylcholine receptor protein alpha-7 subunit agonist 2 Other Other
CHEMBL214268 PHA-543613 Neuronal acetylcholine receptor protein alpha-7 subunit agonist 1 PubMed PubMed
CHEMBL429317 AVL-3288 Neuronal acetylcholine receptor protein alpha-7 subunit positive allosteric modulator 1 Other PubMed PubMed PubMed
CHEMBL2151570 ABT-107 Neuronal acetylcholine receptor protein alpha-7 subunit agonist 1 PubMed PubMed
CHEMBL3545013 APN1125 Neuronal acetylcholine receptor protein alpha-7 subunit partial agonist 1 DOI
More...

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000175344
Ensembl ENSG00000175344
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005892 (acetylcholine-gated channel complex)
GO:0009897 (external side of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016324 (apical plasma membrane)
GO:0030054 (cell junction)
GO:0030673 (axolemma)
GO:0044853 (plasma membrane raft)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO:0098794 (postsynapse)
GO Molecular Function GO:0001540 (beta-amyloid binding)
GO:0004888 (transmembrane signaling receptor activity)
GO:0005216 (ion channel activity)
GO:0005230 (extracellular ligand-gated ion channel activity)
GO:0005262 (calcium channel activity)
GO:0005515 (protein binding)
GO:0015276 (ligand-gated ion channel activity)
GO:0015464 (acetylcholine receptor activity)
GO:0015643 (toxic substance binding)
GO:0017081 (chloride channel regulator activity)
GO:0022848 (acetylcholine-gated cation channel activity)
GO:0042166 (acetylcholine binding)
GO:0042803 (protein homodimerization activity)
GO Biological Process GO:0000187 (activation of MAPK activity)
GO:0001666 (response to hypoxia)
GO:0001933 (negative regulation of protein phosphorylation)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0001988 (positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure)
GO:0006811 (ion transport)
GO:0006816 (calcium ion transport)
GO:0006874 (cellular calcium ion homeostasis)
GO:0006897 (endocytosis)
GO:0007165 (signal transduction)
GO:0007271 (synaptic transmission, cholinergic)
GO:0007611 (learning or memory)
GO:0007613 (memory)
GO:0007614 (short-term memory)
GO:0008284 (positive regulation of cell proliferation)
GO:0008306 (associative learning)
GO:0009409 (response to cold)
GO:0014061 (regulation of norepinephrine secretion)
GO:0030317 (sperm motility)
GO:0032094 (response to food)
GO:0032225 (regulation of synaptic transmission, dopaminergic)
GO:0032691 (negative regulation of interleukin-1 beta production)
GO:0032715 (negative regulation of interleukin-6 production)
GO:0032720 (negative regulation of tumor necrosis factor production)
GO:0033138 (positive regulation of peptidyl-serine phosphorylation)
GO:0034220 (ion transmembrane transport)
GO:0035094 (response to nicotine)
GO:0035095 (behavioral response to nicotine)
GO:0042110 (T cell activation)
GO:0042113 (B cell activation)
GO:0042391 (regulation of membrane potential)
GO:0042698 (ovulation cycle)
GO:0045471 (response to ethanol)
GO:0045766 (positive regulation of angiogenesis)
GO:0048149 (behavioral response to ethanol)
GO:0050727 (regulation of inflammatory response)
GO:0050728 (negative regulation of inflammatory response)
GO:0050804 (modulation of synaptic transmission)
GO:0050808 (synapse organization)
GO:0050890 (cognition)
GO:0050893 (sensory processing)
GO:0051247 (positive regulation of protein metabolic process)
GO:0060078 (regulation of postsynaptic membrane potential)
GO:0060079 (excitatory postsynaptic potential)
GO:0060112 (generation of ovulation cycle rhythm)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0070588 (calcium ion transmembrane transport)
GO:0095500 (acetylcholine receptor signaling pathway)
GO:0097061 (dendritic spine organization)
GO:0098815 (modulation of excitatory postsynaptic potential)
GO:0140059 (dendrite arborization)
GO:1900273 (positive regulation of long-term synaptic potentiation)
GO:1901214 (regulation of neuron death)
GO:1902004 (positive regulation of beta-amyloid formation)
GO:1902430 (negative regulation of beta-amyloid formation)
GO:1902991 (regulation of amyloid precursor protein catabolic process)
GO:1904645 (response to amyloid-beta)
GO:1905144 (response to acetylcholine)
GO:1905906 (regulation of amyloid fibril formation)
GO:1905920 (positive regulation of CoA-transferase activity)
GO:2000463 (positive regulation of excitatory postsynaptic potential)
Wikipedia CHRNA7

Target Cross References - Protein

canSAR P36544
Human Protein Atlas ENSG00000175344
IntAct P36544
Guide to Pharmacology 468
MICAD NBK23663 (Neuronal alpha7 nicotinic acetylcholine receptor (nAChR))
Open Targets ENSG00000175344
PharmGKB PA114
Pharos P36544 (Tchem)
Reactome R-HSA-629594 (Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.)
UniProt A8K7Q4 B4DFS0 P36544 Q15826 Q8IUZ4 Q96RH2 Q99555 Q9BXH0

Target Cross References - Domain

InterPro IPR002394 (Nicotinic_acetylcholine_rcpt.)
IPR006029 (Neurotrans-gated_channel_TM.)
IPR006201 (Neur_channel.)
IPR006202 (Neur_chan_lig-bd.)
IPR018000 (Neurotransmitter_ion_chnl_CS.)
IPR036719 (Neuro-gated_channel_TM_sf.)
IPR036734 (Neur_chan_lig-bd_sf.)
Pfam PF02931 (Neur_chan_LBD)
PF02932 (Neur_chan_memb)

Target Cross References - Structure

PDBe 5AFH 5AFJ 5AFK 5AFL 5AFM 5AFN
CREDO 5AFH 5AFJ 5AFK 5AFL 5AFM 5AFN
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