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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2490
Target Type SINGLE PROTEIN
Preferred Name Serotonin 2a (5-HT2a) receptor
Synonyms 5-HT-2 | 5-HT-2A | 5-HT2A | 5-hydroxytryptamine receptor 2A | HTR2A | Serotonin receptor 2A
Organism Sus scrofa
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > serotonin receptor

Target Components

Component Description Relationship Accession
5-hydroxytryptamine receptor 2A SINGLE PROTEIN P50129

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005901 (caveola)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016023 (cytoplasmic, membrane-bounded vesicle)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0031410 (cytoplasmic vesicle)
GO:0042995 (cell projection)
GO:0043198 (dendritic shaft)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004993 (G-protein coupled serotonin receptor activity)
GO Biological Process GO:0006939 (smooth muscle contraction)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007210 (serotonin receptor signaling pathway)
GO:0007610 (behavior)
GO:0046883 (regulation of hormone secretion)
GO:0050795 (regulation of behavior)

Target Cross References - Protein

canSAR P50129
UniProt P50129 Q29004

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000455 (5HT2A_rcpt.)
IPR002231 (5HT_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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