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Target Report Card

Target Name and Classification

Target ID CHEMBL2487
Preferred Name Beta amyloid A4 protein
Synonyms A4 | ABPP | AD1 | AICD-50 | AICD-57 | AICD-59 | AID(50) | AID(57) | AID(59) | APP | APP | APPI | Alzheimer disease amyloid protein | Amyloid beta A4 protein | Amyloid intracellular domain 50 | Amyloid intracellular domain 57 | Amyloid intracellular domain 59 | Amyloid precursor protein | Beta-APP40 | Beta-APP42 | Beta-amyloid precursor protein | Beta-amyloid protein 40 | Beta-amyloid protein 42 | C31 | C80 | C83 | C99 | CVAP | Cerebral vascular amyloid peptide | Gamma-CTF(50) | Gamma-CTF(57) | Gamma-CTF(59) | Gamma-secretase C-terminal fragment 50 | Gamma-secretase C-terminal fragment 57 | Gamma-secretase C-terminal fragment 59 | N-APP | P3(40) | P3(42) | PN-II | PreA4 | Protease nexin-II | S-APP-alpha | S-APP-beta | Soluble APP-alpha | Soluble APP-beta
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor

Target Components

Component Description Relationship Accession
Amyloid beta A4 protein SINGLE PROTEIN P05067

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1743004 CRENEZUMAB Beta amyloid A4 protein other 3 Other PubMed
CHEMBL1743025 GANTENERUMAB Beta amyloid A4 protein other 3 PubMed
CHEMBL1743072 SOLANEZUMAB Beta amyloid A4 protein other 3 PubMed
CHEMBL2108576 BAPINEUZUMAB Beta amyloid A4 protein other 3 PubMed
CHEMBL3039540 ADUCANUMAB Beta amyloid A4 protein other 3 PubMed
CHEMBL1743058 PONEZUMAB Beta amyloid A4 protein other 2 PubMed
CHEMBL2109300 GSK-933776 Beta amyloid A4 protein other 2 PubMed
CHEMBL3833321 BAN2401 Beta amyloid A4 protein inhibitor 0 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000142192
Ensembl ENSG00000142192
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005641 (nuclear envelope lumen)
GO:0005737 (cytoplasm)
GO:0005768 (endosome)
GO:0005790 (smooth endoplasmic reticulum)
GO:0005791 (rough endoplasmic reticulum)
GO:0005794 (Golgi apparatus)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005905 (clathrin-coated pit)
GO:0005911 (cell-cell junction)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030134 (ER to Golgi transport vesicle)
GO:0030424 (axon)
GO:0030426 (growth cone)
GO:0031093 (platelet alpha granule lumen)
GO:0031410 (cytoplasmic vesicle)
GO:0031594 (neuromuscular junction)
GO:0031904 (endosome lumen)
GO:0032588 (trans-Golgi network membrane)
GO:0035253 (ciliary rootlet)
GO:0043005 (neuron projection)
GO:0043195 (terminal bouton)
GO:0043197 (dendritic spine)
GO:0043198 (dendritic shaft)
GO:0043231 (intracellular membrane-bounded organelle)
GO:0043235 (receptor complex)
GO:0044304 (main axon)
GO:0045121 (membrane raft)
GO:0045177 (apical part of cell)
GO:0045202 (synapse)
GO:0048471 (perinuclear region of cytoplasm)
GO:0051233 (spindle midzone)
GO:0070062 (extracellular exosome)
GO:0097449 (astrocyte projection)
GO:1990761 (growth cone lamellipodium)
GO:1990812 (growth cone filopodium)
GO Molecular Function GO:0003677 (DNA binding)
GO:0004867 (serine-type endopeptidase inhibitor activity)
GO:0005102 (receptor binding)
GO:0005515 (protein binding)
GO:0008201 (heparin binding)
GO:0016504 (peptidase activator activity)
GO:0019899 (enzyme binding)
GO:0030414 (peptidase inhibitor activity)
GO:0033130 (acetylcholine receptor binding)
GO:0042802 (identical protein binding)
GO:0046872 (metal ion binding)
GO:0046914 (transition metal ion binding)
GO:0051425 (PTB domain binding)
GO:0070851 (growth factor receptor binding)
GO Biological Process GO:0001878 (response to yeast)
GO:0001967 (suckling behavior)
GO:0002576 (platelet degranulation)
GO:0006378 (mRNA polyadenylation)
GO:0006417 (regulation of translation)
GO:0006468 (protein phosphorylation)
GO:0006878 (cellular copper ion homeostasis)
GO:0006897 (endocytosis)
GO:0006915 (apoptotic process)
GO:0006979 (response to oxidative stress)
GO:0007155 (cell adhesion)
GO:0007176 (regulation of epidermal growth factor-activated receptor activity)
GO:0007219 (Notch signaling pathway)
GO:0007399 (nervous system development)
GO:0007409 (axonogenesis)
GO:0007617 (mating behavior)
GO:0007626 (locomotory behavior)
GO:0008088 (axo-dendritic transport)
GO:0008203 (cholesterol metabolic process)
GO:0008344 (adult locomotory behavior)
GO:0008542 (visual learning)
GO:0009987 (cellular process)
GO:0010288 (response to lead ion)
GO:0010466 (negative regulation of peptidase activity)
GO:0010468 (regulation of gene expression)
GO:0010951 (negative regulation of endopeptidase activity)
GO:0010952 (positive regulation of peptidase activity)
GO:0010971 (positive regulation of G2/M transition of mitotic cell cycle)
GO:0016199 (axon midline choice point recognition)
GO:0016322 (neuron remodeling)
GO:0016358 (dendrite development)
GO:0019731 (antibacterial humoral response)
GO:0019732 (antifungal humoral response)
GO:0030198 (extracellular matrix organization)
GO:0030900 (forebrain development)
GO:0031175 (neuron projection development)
GO:0035235 (ionotropic glutamate receptor signaling pathway)
GO:0040014 (regulation of multicellular organism growth)
GO:0043393 (regulation of protein binding)
GO:0044267 (cellular protein metabolic process)
GO:0045087 (innate immune response)
GO:0045665 (negative regulation of neuron differentiation)
GO:0045931 (positive regulation of mitotic cell cycle)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048669 (collateral sprouting in absence of injury)
GO:0050803 (regulation of synapse structure or activity)
GO:0050829 (defense response to Gram-negative bacterium)
GO:0050830 (defense response to Gram-positive bacterium)
GO:0050885 (neuromuscular process controlling balance)
GO:0051124 (synaptic growth at neuromuscular junction)
GO:0051402 (neuron apoptotic process)
GO:0051563 (smooth endoplasmic reticulum calcium ion homeostasis)
GO:0071320 (cellular response to cAMP)
GO:0071874 (cellular response to norepinephrine stimulus)
GO:1990000 (amyloid fibril formation)
GO:1990090 (cellular response to nerve growth factor stimulus)
Wikipedia Amyloid_precursor_protein

Target Cross References - Protein

canSAR P05067
CGD Alzheimer disease, familial; Cerebral amyloid angiopathy
Human Protein Atlas ENSG00000142192
IntAct P05067
MICAD NBK23203 (Aggregates of Amyloid-beta peptide)
NBK23213 (Aggregates of Beta-amyloid peptides)
NBK23443 (Aggregates of Beta-amyloid peptide)
NBK32300 (Amyloid-beta peptide)
NBK57129 (Amyloid-beta peptide)
NBK82968 (Beta-amyloid)
NBK82969 (Beta-amyloid (A-beta))
NBK84117 (Beta-amyloid plaques)
Open Targets ENSG00000142192
PharmGKB PA24910
Reactome R-HSA-114608 (Platelet degranulation.)
R-HSA-1810476 (RIP-mediated NFkB activation via ZBP1.)
R-HSA-3000178 (ECM proteoglycans.)
R-HSA-3134963 (DEx/H-box helicases activate type I IFN and inflammatory cytokines production.)
R-HSA-416476 (G alpha (q) signalling events.)
R-HSA-418594 (G alpha (i) signalling events.)
R-HSA-432720 (Lysosome Vesicle Biogenesis.)
R-HSA-444473 (Formyl peptide receptors bind formyl peptides and many other ligands.)
R-HSA-445989 (TAK1 activates NFkB by phosphorylation and activation of IKKs complex.)
R-HSA-844456 (The NLRP3 inflammasome.)
R-HSA-879415 (Advanced glycosylation endproduct receptor signaling.)
R-HSA-8862803 (Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models.)
R-HSA-933542 (TRAF6 mediated NF-kB activation.)
R-HSA-977225 (Amyloid fiber formation.)
UniProt B2R5V1 B4DII8 D3DSD1 D3DSD2 D3DSD3 P05067 P09000 P78438 Q13764 Q13778 Q13793 Q16011 Q16014 Q16019 Q16020 Q6GSC0 Q8WZ99 Q9BT38 Q9UC33 Q9UCA9 Q9UCB6 Q9UCC8 Q9UCD1 Q9UQ58

Target Cross References - Domain

InterPro IPR002223 (Kunitz_BPTI.)
IPR008154 (Amyloid_glyco_extra.)
IPR008155 (Amyloid_glyco.)
IPR011178 (Amyloid_glyco_Cu-bd.)
IPR013803 (Amyloid_glyco_Abeta.)
IPR015849 (Amyloid_glyco_heparin-bd.)
IPR019543 (APP_amyloid_C.)
IPR019744 (Amyloid_glyco_extracell_CS.)
IPR019745 (Amyloid_glyco_intracell_CS.)
IPR020901 (Prtase_inh_Kunz-CS.)
IPR024329 (Amyloid_glyco_E2_domain.)
IPR028866 (APP.)
Pfam PF00014 (Kunitz_BPTI)
PF02177 (APP_N)
PF03494 (Beta-APP)
PF10515 (APP_amyloid)
PF12924 (APP_Cu_bd)
PF12925 (APP_E2)

Target Cross References - Structure

PDBe 1AAP 1BRC 1CA0 1MWP 1TAW 1X11 1ZJD 2FJZ 2FK1 2FK2 2FK3 2FKL 2FMA 2G47 2IPU 2R0W 2WK3 2Y29 2Y2A 2Y3J 2Y3K 2Y3L 3AYU 3BAE More...
CREDO 1AAP 1BRC 1CA0 1MWP 1TAW 1X11 1ZJD 2FJZ 2FK1 2FK2 2FK3 2FKL 2FMA 2G47 2IPU 2R0W 2WK3 2Y29 2Y2A 2Y3J 2Y3K 2Y3L 3AYU 3BAE More...