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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2483
Target Type SINGLE PROTEIN
Preferred Name Cytochrome P450 2D2
Synonyms CYPIID26 | Cyp2d-26 | Cyp2d2 | Cyp2d26 | Cytochrome P450 2D26 | Cytochrome P450-CMF2 | Cytochrome P450-DB2 | Debrisoquine 4-hydroxylase
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • enzyme > cytochrome p450 > cytochrome p450 family 2 > cytochrome p450 family 2d > cytochrome p450 2d2

Target Components

Component Description Relationship Accession
Cytochrome P450 2D26 SINGLE PROTEIN P10634

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005737 (cytoplasm)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016020 (membrane)
GO:0031090 (organelle membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0004497 (monooxygenase activity)
GO:0005506 (iron ion binding)
GO:0008395 (steroid hydroxylase activity)
GO:0016491 (oxidoreductase activity)
GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
GO:0016712 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen)
GO:0020037 (heme binding)
GO:0046872 (metal ion binding)
GO:0070330 (aromatase activity)
GO Biological Process GO:0006082 (organic acid metabolic process)
GO:0006805 (xenobiotic metabolic process)
GO:0007565 (female pregnancy)
GO:0019369 (arachidonic acid metabolic process)
GO:0042493 (response to drug)
GO:0042738 (exogenous drug catabolic process)

Target Cross References - Protein

canSAR P10634
IntAct P10634
Reactome R-RNO-211935 (Fatty acids.)
R-RNO-211958 (Miscellaneous substrates.)
R-RNO-211981 (Xenobiotics.)
R-RNO-211999 (CYP2E1 reactions.)
R-RNO-9027307 (Biosynthesis of maresin-like SPMs.)
UniProt P10634

Target Cross References - Domain

InterPro IPR001128 (Cyt_P450.)
IPR002401 (Cyt_P450_E_grp-I.)
IPR008069 (Cyt_P450_E_grp-I_CYP2D-like.)
IPR017972 (Cyt_P450_CS.)
IPR036396 (Cyt_P450_sf.)
Pfam PF00067 (p450)
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