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Target Report Card

Target Name and Classification

Target ID CHEMBL2480
Preferred Name Tyrosine-protein kinase LCK
Synonyms LSK | Lck | Leukocyte C-terminal Src kinase | Lsk-t | Lymphocyte cell-specific protein-tyrosine kinase | Proto-oncogene tyrosine-protein kinase LCK | p56-LCK
Organism Mus musculus
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase src family

Target Components

Component Description Relationship Accession
Proto-oncogene tyrosine-protein kinase LCK SINGLE PROTEIN P06240

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0000242 (pericentriolar material)
GO:0001772 (immunological synapse)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005911 (cell-cell junction)
GO:0016020 (membrane)
GO:0030139 (endocytic vesicle)
GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane)
GO:0045121 (membrane raft)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0001784 (phosphotyrosine binding)
GO:0003823 (antigen binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0004722 (protein serine/threonine phosphatase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008022 (protein C-terminus binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019901 (protein kinase binding)
GO:0019903 (protein phosphatase binding)
GO:0042169 (SH2 domain binding)
GO:0042608 (T cell receptor binding)
GO:0042609 (CD4 receptor binding)
GO:0042610 (CD8 receptor binding)
GO:0042802 (identical protein binding)
GO:0043548 (phosphatidylinositol 3-kinase binding)
GO:0044877 (macromolecular complex binding)
GO:0051117 (ATPase binding)
GO:1990405 (protein antigen binding)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0006470 (protein dephosphorylation)
GO:0006882 (cellular zinc ion homeostasis)
GO:0006919 (activation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0007166 (cell surface receptor signaling pathway)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0009612 (response to mechanical stimulus)
GO:0010038 (response to metal ion)
GO:0010628 (positive regulation of gene expression)
GO:0016310 (phosphorylation)
GO:0016477 (cell migration)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0030217 (T cell differentiation)
GO:0038083 (peptidyl-tyrosine autophosphorylation)
GO:0042127 (regulation of cell proliferation)
GO:0042493 (response to drug)
GO:0042531 (positive regulation of tyrosine phosphorylation of STAT protein)
GO:0042542 (response to hydrogen peroxide)
GO:0042981 (regulation of apoptotic process)
GO:0045087 (innate immune response)
GO:0045588 (positive regulation of gamma-delta T cell differentiation)
GO:0045589 (regulation of regulatory T cell differentiation)
GO:0046777 (protein autophosphorylation)
GO:0050853 (B cell receptor signaling pathway)
GO:0050856 (regulation of T cell receptor signaling pathway)
GO:0050870 (positive regulation of T cell activation)
GO:0051209 (release of sequestered calcium ion into cytosol)
GO:0070474 (positive regulation of uterine smooth muscle contraction)
GO:2001244 (positive regulation of intrinsic apoptotic signaling pathway)

Target Cross References - Protein

canSAR P06240
IntAct P06240
Reactome R-MMU-114604 (GPVI-mediated activation cascade.)
R-MMU-1257604 (PIP3 activates AKT signaling.)
R-MMU-1433557 (Signaling by SCF-KIT.)
R-MMU-1433559 (Regulation of KIT signaling.)
R-MMU-202424 (Downstream TCR signaling.)
R-MMU-202427 (Phosphorylation of CD3 and TCR zeta chains.)
R-MMU-202430 (Translocation of ZAP-70 to Immunological synapse.)
R-MMU-202433 (Generation of second messenger molecules.)
R-MMU-2424491 (DAP12 signaling.)
R-MMU-389356 (CD28 co-stimulation.)
R-MMU-389357 (CD28 dependent PI3K/Akt signaling.)
R-MMU-389359 (CD28 dependent Vav1 pathway.)
R-MMU-389513 (CTLA4 inhibitory signaling.)
R-MMU-389948 (PD-1 signaling.)
R-MMU-6811558 (PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.)
R-MMU-9020558 (Interleukin-2 signaling.)
UniProt P06240 Q61794 Q61795 Q62320 Q91X65

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR000980 (SH2.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001452 (SH3_domain.)
IPR008266 (Tyr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR035749 (Lck_SH3.)
IPR035850 (Lck_SH2.)
IPR036028 (SH3-like_dom_sf.)
IPR036860 (SH2_dom_sf.)
Pfam PF00017 (SH2)
PF00018 (SH3_1)
PF07714 (Pkinase_Tyr)