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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2478
Target Type SINGLE PROTEIN
Preferred Name Salivary alpha-amylase
Synonyms 1,4-alpha-D-glucan glucanohydrolase 1 | AMY1 | AMY1C | Alpha-amylase 1 | Salivary alpha-amylase | andAMY1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Alpha-amylase 1 SINGLE PROTEIN P04745

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000174876 ENSG00000187733 ENSG00000237763
Ensembl ENSG00000174876 ENSG00000187733 ENSG00000237763
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0003824 (catalytic activity)
GO:0004556 (alpha-amylase activity)
GO:0005515 (protein binding)
GO:0016787 (hydrolase activity)
GO:0016798 (hydrolase activity, acting on glycosyl bonds)
GO:0043169 (cation binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0005975 (carbohydrate metabolic process)
GO:0007586 (digestion)
GO:0008152 (metabolic process)
Wikipedia AMY1A

Target Cross References - Protein

canSAR P04745
Human Protein Atlas ENSG00000174876 ENSG00000187733 ENSG00000237763
IntAct P04745
Open Targets ENSG00000174876 ENSG00000187733 ENSG00000237763
PharmGKB PA24783
Reactome R-HSA-189085 (Digestion of dietary carbohydrate.)
UniProt A6NJS5 A8K8H6 P04745 Q13763 Q5T083

Target Cross References - Domain

InterPro IPR006046 (Alpha_amylase.)
IPR006047 (Glyco_hydro_13_cat_dom.)
IPR006048 (A-amylase/branching_C.)
IPR013780 (Glyco_hydro_b.)
IPR013781 (Glyco_hydro_catalytic_dom.)
IPR017853 (Glycoside_hydrolase_SF.)
IPR031319 (A-amylase_C.)
Pfam PF00128 (Alpha-amylase)
PF02806 (Alpha-amylase_C)

Target Cross References - Structure

PDBe 1C8Q 1JXJ 1JXK 1MFU 1MFV 1NM9 1Q4N 1SMD 1XV8 1Z32 3BLK 3BLP 3DHP
CREDO 1C8Q 1JXJ 1JXK 1MFU 1MFV 1NM9 1Q4N 1SMD 1XV8 1Z32 3BLK 3BLP 3DHP
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