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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2474
Target Type SINGLE PROTEIN
Preferred Name Methionine aminopeptidase 1
Synonyms KIAA0094 | MAP 1 | METAP1 | MetAP 1 | Methionine aminopeptidase 1 | Peptidase M 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mg clan > metallo protease m24a subfamily

Target Components

Component Description Relationship Accession
Methionine aminopeptidase 1 SINGLE PROTEIN P53582

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3831223 Aminopeptidase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000164024
Ensembl ENSG00000164024
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0022626 (cytosolic ribosome)
GO Molecular Function GO:0004177 (aminopeptidase activity)
GO:0008233 (peptidase activity)
GO:0008235 (metalloexopeptidase activity)
GO:0016787 (hydrolase activity)
GO:0046872 (metal ion binding)
GO:0070006 (metalloaminopeptidase activity)
GO Biological Process GO:0006417 (regulation of translation)
GO:0006508 (proteolysis)
GO:0018206 (peptidyl-methionine modification)
GO:0022400 (regulation of rhodopsin mediated signaling pathway)
GO:0031365 (N-terminal protein amino acid modification)
GO:0070084 (protein initiator methionine removal)
GO:0070527 (platelet aggregation)
Wikipedia METAP1

Target Cross References - Protein

canSAR P53582
Human Protein Atlas ENSG00000164024
IntAct P53582
Guide to Pharmacology 1572
Open Targets ENSG00000164024
PharmGKB PA30764
Reactome R-HSA-2514859 (Inactivation, recovery and regulation of the phototransduction cascade.)
UniProt B4E2E6 P53582

Target Cross References - Domain

InterPro IPR000994 (Pept_M24.)
IPR001714 (Pept_M24_MAP.)
IPR002467 (Pept_M24A_MAP1.)
IPR031615 (Zfn-C6H2.)
Pfam PF00557 (Peptidase_M24)
PF15801 (zf-C6H2)

Target Cross References - Structure

PDBe 2B3H 2B3K 2B3L 2G6P 2GZ5 2NQ6 2NQ7 4FLI 4FLJ 4FLK 4FLL 4HXX 4IKR 4IKS 4IKT 4IKU 4IU6 4U1B 4U69 4U6C 4U6E 4U6J 4U6W 4U6Z More...
CREDO 2B3H 2B3K 2B3L 2G6P 2GZ5 2NQ6 2NQ7 4FLI 4FLJ 4FLK 4FLL 4HXX 4IKR 4IKS 4IKT 4IKU 4IU6 4U1B 4U69 4U6C 4U6E 4U6J 4U6W 4U6Z More...
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