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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL246
Preferred Name Beta-3 adrenergic receptor
Synonyms ADRB3 | ADRB3R | B3AR | Beta-3 adrenergic receptor | Beta-3 adrenoceptor | Beta-3 adrenoreceptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > adrenergic receptor

Target Components

Component Description Relationship Accession
Beta-3 adrenergic receptor SINGLE PROTEIN P13945

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2097169 Adrenergic receptor beta; ADRB1 & ADRB3 SELECTIVITY GROUP
CHEMBL2331074 Adrenergic receptor PROTEIN FAMILY
CHEMBL2111388 Beta-2 adrenergic receptor and beta-3 adrenergic receptor SELECTIVITY GROUP
CHEMBL2094118 Adrenergic receptor beta PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2095212 MIRABEGRON Beta-3 adrenergic receptor agonist 4 Expert
CHEMBL545437 AMIBEGRON HYDROCHLORIDE Beta-3 adrenergic receptor agonist 3 PubMed
CHEMBL2107773 RITOBEGRON Beta-3 adrenergic receptor agonist 3 PubMed
CHEMBL279260 RAFABEGRON Beta-3 adrenergic receptor agonist 2 PubMed
CHEMBL208427 SOLABEGRON Beta-3 adrenergic receptor agonist 2 PubMed PubMed
CHEMBL2012520 LY377604 Beta-3 adrenergic receptor agonist 2 PubMed
CHEMBL2107826 VIBEGRON Beta-3 adrenergic receptor agonist 2 Other Other

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000188778
Ensembl ENSG00000188778
GO Cellular Component GO:0005634 (nucleus)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043235 (receptor complex)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004935 (adrenergic receptor activity)
GO:0004939 (beta-adrenergic receptor activity)
GO:0005515 (protein binding)
GO:0015052 (beta3-adrenergic receptor activity)
GO:0031699 (beta-3 adrenergic receptor binding)
GO:0042803 (protein homodimerization activity)
GO:0051379 (epinephrine binding)
GO:0051380 (norepinephrine binding)
GO Biological Process GO:0001659 (temperature homeostasis)
GO:0002024 (diet induced thermogenesis)
GO:0002025 (vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure)
GO:0002032 (desensitization of G-protein coupled receptor protein signaling pathway by arrestin)
GO:0005975 (carbohydrate metabolic process)
GO:0006091 (generation of precursor metabolites and energy)
GO:0006112 (energy reserve metabolic process)
GO:0006898 (receptor-mediated endocytosis)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007187 (G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)
GO:0007188 (adenylate cyclase-modulating G-protein coupled receptor signaling pathway)
GO:0007189 (adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:0007190 (activation of adenylate cyclase activity)
GO:0007267 (cell-cell signaling)
GO:0007568 (aging)
GO:0009409 (response to cold)
GO:0031649 (heat generation)
GO:0040015 (negative regulation of multicellular organism growth)
GO:0042755 (eating behavior)
GO:0043410 (positive regulation of MAPK cascade)
GO:0046677 (response to antibiotic)
GO:0050873 (brown fat cell differentiation)
GO:0071880 (adenylate cyclase-activating adrenergic receptor signaling pathway)
Wikipedia Beta-3_adrenergic_receptor

Target Cross References - Protein

canSAR P13945
Human Protein Atlas ENSG00000188778
IntAct P13945
Guide to Pharmacology 30
Open Targets ENSG00000188778
PharmGKB PA24598
Pharos P13945 (Tclin)
Reactome R-HSA-390696 (Adrenoceptors.)
R-HSA-418555 (G alpha (s) signalling events.)
UniProt P13945 Q4JFT4

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000681 (ADRB3_rcpt.)
IPR002233 (ADR_fam.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)