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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL246
Preferred Name Beta-3 adrenergic receptor
Synonyms ADRB3 | ADRB3R | B3AR | Beta-3 adrenergic receptor | Beta-3 adrenoceptor | Beta-3 adrenoreceptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > adrenergic receptor

Target Components

Component Description Relationship Accession
Beta-3 adrenergic receptor SINGLE PROTEIN P13945

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2097169 Adrenergic receptor beta; ADRB1 & ADRB3 SELECTIVITY GROUP
CHEMBL2111388 Beta-2 adrenergic receptor and beta-3 adrenergic receptor SELECTIVITY GROUP
CHEMBL2094118 Adrenergic receptor beta PROTEIN FAMILY
CHEMBL2331074 Adrenergic receptor PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2095212 MIRABEGRON Beta-3 adrenergic receptor agonist 4 Expert
CHEMBL545437 AMIBEGRON HYDROCHLORIDE Beta-3 adrenergic receptor agonist 3 PubMed
CHEMBL2107773 RITOBEGRON Beta-3 adrenergic receptor agonist 3 PubMed
CHEMBL279260 RAFABEGRON Beta-3 adrenergic receptor agonist 2 PubMed
CHEMBL208427 SOLABEGRON Beta-3 adrenergic receptor agonist 2 PubMed PubMed
CHEMBL2012520 LY377604 Beta-3 adrenergic receptor agonist 2 PubMed
CHEMBL2107826 VIBEGRON Beta-3 adrenergic receptor agonist 2 Other Other

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000188778
Ensembl ENSG00000188778
GO Cellular Component GO:0005634 (nucleus)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043235 (receptor complex)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004935 (adrenergic receptor activity)
GO:0004939 (beta-adrenergic receptor activity)
GO:0005515 (protein binding)
GO:0015052 (beta3-adrenergic receptor activity)
GO:0031699 (beta-3 adrenergic receptor binding)
GO:0042803 (protein homodimerization activity)
GO:0051379 (epinephrine binding)
GO:0051380 (norepinephrine binding)
GO Biological Process GO:0001659 (temperature homeostasis)
GO:0002024 (diet induced thermogenesis)
GO:0002025 (vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure)
GO:0002032 (desensitization of G-protein coupled receptor protein signaling pathway by arrestin)
GO:0005975 (carbohydrate metabolic process)
GO:0006091 (generation of precursor metabolites and energy)
GO:0006112 (energy reserve metabolic process)
GO:0006898 (receptor-mediated endocytosis)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007187 (G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)
GO:0007188 (adenylate cyclase-modulating G-protein coupled receptor signaling pathway)
GO:0007189 (adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:0007190 (activation of adenylate cyclase activity)
GO:0007267 (cell-cell signaling)
GO:0007568 (aging)
GO:0009409 (response to cold)
GO:0031649 (heat generation)
GO:0040015 (negative regulation of multicellular organism growth)
GO:0042755 (eating behavior)
GO:0043410 (positive regulation of MAPK cascade)
GO:0046677 (response to antibiotic)
GO:0050873 (brown fat cell differentiation)
GO:0071880 (adenylate cyclase-activating adrenergic receptor signaling pathway)
Wikipedia Beta-3_adrenergic_receptor

Target Cross References - Protein

canSAR P13945
Human Protein Atlas ENSG00000188778
IntAct P13945
Guide to Pharmacology 30
Open Targets ENSG00000188778
PharmGKB PA24598
Pharos P13945 (Tclin)
Reactome R-HSA-390696 (Adrenoceptors.)
R-HSA-418555 (G alpha (s) signalling events.)
UniProt P13945 Q4JFT4

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000681 (ADRB3_rcpt.)
IPR002233 (ADR_fam.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)