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Target Report Card

Target Name and Classification

Target ID CHEMBL2459
Preferred Name Peroxisome proliferator-activated receptor gamma
Synonyms Nr1c3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | Peroxisome proliferator-activated receptor gamma | Pparg
Organism Mus musculus
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 1 > nuclear hormone receptor subfamily 1 group c > nuclear hormone receptor subfamily 1 group c member 3

Target Components

Component Description Relationship Accession
Peroxisome proliferator-activated receptor gamma SINGLE PROTEIN P37238

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0032991 (macromolecular complex)
GO:0043231 (intracellular membrane-bounded organelle)
GO:0048471 (perinuclear region of cytoplasm)
GO:0090575 (RNA polymerase II transcription factor complex)
GO Molecular Function GO:0001012 (RNA polymerase II regulatory region DNA binding)
GO:0001046 (core promoter sequence-specific DNA binding)
GO:0001228 (transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding)
GO:0003677 (DNA binding)
GO:0003682 (chromatin binding)
GO:0003690 (double-stranded DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003707 (steroid hormone receptor activity)
GO:0004879 (RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding)
GO:0005515 (protein binding)
GO:0008022 (protein C-terminus binding)
GO:0008134 (transcription factor binding)
GO:0008144 (drug binding)
GO:0008270 (zinc ion binding)
GO:0019899 (enzyme binding)
GO:0019903 (protein phosphatase binding)
GO:0030331 (estrogen receptor binding)
GO:0030374 (ligand-dependent nuclear receptor transcription coactivator activity)
GO:0033613 (activating transcription factor binding)
GO:0042277 (peptide binding)
GO:0042802 (identical protein binding)
GO:0043565 (sequence-specific DNA binding)
GO:0043621 (protein self-association)
GO:0044212 (transcription regulatory region DNA binding)
GO:0046872 (metal ion binding)
GO:0046965 (retinoid X receptor binding)
GO:0046982 (protein heterodimerization activity)
GO:0050544 (arachidonic acid binding)
GO:0050692 (DBD domain binding)
GO:0050693 (LBD domain binding)
GO:0050699 (WW domain binding)
GO:0051393 (alpha-actinin binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0001818 (negative regulation of cytokine production)
GO:0001890 (placenta development)
GO:0002021 (response to dietary excess)
GO:0002024 (diet induced thermogenesis)
GO:0002674 (negative regulation of acute inflammatory response)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006357 (regulation of transcription from RNA polymerase II promoter)
GO:0006919 (activation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0006954 (inflammatory response)
GO:0007165 (signal transduction)
GO:0008217 (regulation of blood pressure)
GO:0008285 (negative regulation of cell proliferation)
GO:0009416 (response to light stimulus)
GO:0010468 (regulation of gene expression)
GO:0010742 (macrophage derived foam cell differentiation)
GO:0010745 (negative regulation of macrophage derived foam cell differentiation)
GO:0010871 (negative regulation of receptor biosynthetic process)
GO:0010887 (negative regulation of cholesterol storage)
GO:0010891 (negative regulation of sequestering of triglyceride)
GO:0015909 (long-chain fatty acid transport)
GO:0016525 (negative regulation of angiogenesis)
GO:0019216 (regulation of lipid metabolic process)
GO:0019395 (fatty acid oxidation)
GO:0030224 (monocyte differentiation)
GO:0030308 (negative regulation of cell growth)
GO:0030855 (epithelial cell differentiation)
GO:0032094 (response to food)
GO:0032526 (response to retinoic acid)
GO:0032869 (cellular response to insulin stimulus)
GO:0032966 (negative regulation of collagen biosynthetic process)
GO:0033993 (response to lipid)
GO:0035357 (peroxisome proliferator activated receptor signaling pathway)
GO:0042593 (glucose homeostasis)
GO:0042752 (regulation of circadian rhythm)
GO:0042953 (lipoprotein transport)
GO:0043065 (positive regulation of apoptotic process)
GO:0043388 (positive regulation of DNA binding)
GO:0043401 (steroid hormone mediated signaling pathway)
GO:0043537 (negative regulation of blood vessel endothelial cell migration)
GO:0045165 (cell fate commitment)
GO:0045444 (fat cell differentiation)
GO:0045598 (regulation of fat cell differentiation)
GO:0045600 (positive regulation of fat cell differentiation)
GO:0045713 (low-density lipoprotein particle receptor biosynthetic process)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046321 (positive regulation of fatty acid oxidation)
GO:0048469 (cell maturation)
GO:0048511 (rhythmic process)
GO:0048662 (negative regulation of smooth muscle cell proliferation)
GO:0048714 (positive regulation of oligodendrocyte differentiation)
GO:0050872 (white fat cell differentiation)
GO:0050873 (brown fat cell differentiation)
GO:0051091 (positive regulation of sequence-specific DNA binding transcription factor activity)
GO:0051974 (negative regulation of telomerase activity)
GO:0060100 (positive regulation of phagocytosis, engulfment)
GO:0060336 (negative regulation of interferon-gamma-mediated signaling pathway)
GO:0060850 (regulation of transcription involved in cell fate commitment)
GO:0060965 (negative regulation of gene silencing by miRNA)
GO:0061614 (pri-miRNA transcription by RNA polymerase II)
GO:0071285 (cellular response to lithium ion)
GO:0071404 (cellular response to low-density lipoprotein particle stimulus)
GO:0071407 (cellular response to organic cyclic compound)
GO:0090278 (negative regulation of peptide hormone secretion)
GO:1900077 (negative regulation of cellular response to insulin stimulus)
GO:1904706 (negative regulation of vascular smooth muscle cell proliferation)
GO:1905461 (positive regulation of vascular associated smooth muscle cell apoptotic process)
GO:1905563 (negative regulation of vascular endothelial cell proliferation)
GO:2000230 (negative regulation of pancreatic stellate cell proliferation)

Target Cross References - Protein

canSAR P37238
IntAct P37238
MICAD NBK23231 (Peroxisome proliferator activated receptor gamma)
Reactome R-MMU-442533 (Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes.)
UniProt P37238

Target Cross References - Domain

InterPro IPR000536 (Nucl_hrmn_rcpt_lig-bd.)
IPR001628 (Znf_hrmn_rcpt.)
IPR001723 (Nuclear_hrmn_rcpt.)
IPR003074 (1Cnucl_rcpt.)
IPR003077 (PPAR-gamma.)
IPR013088 (Znf_NHR/GATA.)
IPR022590 (PPARgamma_N.)
IPR035500 (NHR_like_dom_sf.)
Pfam PF00104 (Hormone_recep)
PF00105 (zf-C4)
PF12577 (PPARgamma_N)