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Target Report Card

Target Name and Classification

Target ID CHEMBL2452
Preferred Name Aminopeptidase B
Synonyms AP-B | Aminopeptidase B | Arginine aminopeptidase | Arginyl aminopeptidase | Cytosol aminopeptidase IV | Rnpep
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mae clan > metallo protease m1 family

Target Components

Component Description Relationship Accession
Aminopeptidase B SINGLE PROTEIN O09175

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005794 (Golgi apparatus)
GO:0005886 (plasma membrane)
GO:0009897 (external side of plasma membrane)
GO:0030141 (secretory granule)
GO:0043005 (neuron projection)
GO Molecular Function GO:0004177 (aminopeptidase activity)
GO:0005507 (copper ion binding)
GO:0008233 (peptidase activity)
GO:0008237 (metallopeptidase activity)
GO:0008270 (zinc ion binding)
GO:0016787 (hydrolase activity)
GO:0042277 (peptide binding)
GO:0046872 (metal ion binding)
GO:0050897 (cobalt ion binding)
GO:0070006 (metalloaminopeptidase activity)
GO Biological Process GO:0006508 (proteolysis)
GO:0007568 (aging)
GO:0016485 (protein processing)
GO:0043171 (peptide catabolic process)
GO:0045776 (negative regulation of blood pressure)
GO:0060041 (retina development in camera-type eye)

Target Cross References - Protein

canSAR O09175
UniProt O09175 P97530

Target Cross References - Domain

InterPro IPR001930 (Peptidase_M1.)
IPR014782 (Peptidase_M1_N.)
IPR015211 (Peptidase_M1_C.)
IPR015571 (Pept_M1_aminopeptidase-B.)
IPR016024 (ARM-type_fold.)
IPR034015 (M1_LTA4H.)
Pfam PF01433 (Peptidase_M1)
PF09127 (Leuk-A4-hydro_C)