ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL245
Target Type SINGLE PROTEIN
Preferred Name Muscarinic acetylcholine receptor M3
Synonyms CHRM3 | Muscarinic acetylcholine receptor M3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > acetylcholine receptor

Target Components

Component Description Relationship Accession
Muscarinic acetylcholine receptor M3 SINGLE PROTEIN P20309

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095187 Muscarinic acetylcholine receptors; M2 & M3 SELECTIVITY GROUP
CHEMBL2094109 Muscarinic acetylcholine receptor PROTEIN FAMILY
CHEMBL2111418 Muscarinic acetylcholine receptor M1 and M3 SELECTIVITY GROUP

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL14 CARBACHOL Muscarinic acetylcholine receptor M3 agonist 4 ISBN PubMed PubMed
CHEMBL550 PILOCARPINE Muscarinic acetylcholine receptor M3 agonist 4 ISBN PubMed PubMed PubMed
CHEMBL1133 OXYBUTYNIN CHLORIDE Muscarinic acetylcholine receptor M3 antagonist 4 ISBN PubMed PubMed PubMed PubMed
CHEMBL1184 ACETYLCHOLINE CHLORIDE Muscarinic acetylcholine receptor M3 agonist 4 ISBN PubMed
CHEMBL1231 OXYBUTYNIN Muscarinic acetylcholine receptor M3 antagonist 4 ISBN PubMed PubMed PubMed PubMed
CHEMBL1240 PROPANTHELINE BROMIDE Muscarinic acetylcholine receptor M3 antagonist 4 ISBN PubMed PubMed PubMed PubMed PubMed
CHEMBL517712 ATROPINE Muscarinic acetylcholine receptor M3 antagonist 4 FDA ISBN
CHEMBL1578 ANISOTROPINE METHYLBROMIDE Muscarinic acetylcholine receptor M3 antagonist 4 PubMed PubMed
CHEMBL523299 UMECLIDINIUM BROMIDE Muscarinic acetylcholine receptor M3 antagonist 4 FDA
CHEMBL1724 MEPENZOLATE BROMIDE Muscarinic acetylcholine receptor M3 antagonist 4 ISBN PubMed PubMed
CHEMBL551466 ACLIDINIUM BROMIDE Muscarinic acetylcholine receptor M3 antagonist 4 Expert
CHEMBL1768 BETHANECHOL CHLORIDE Muscarinic acetylcholine receptor M3 agonist 4 ISBN PubMed PubMed
CHEMBL1200330 PILOCARPINE HYDROCHLORIDE Muscarinic acetylcholine receptor M3 agonist 4 ISBN PubMed PubMed PubMed
CHEMBL1200347 ISOPROPAMIDE IODIDE Muscarinic acetylcholine receptor M3 antagonist 4 ISBN PubMed PubMed
CHEMBL1200473 CYCLOPENTOLATE HYDROCHLORIDE Muscarinic acetylcholine receptor M3 antagonist 4 ISBN PubMed
CHEMBL1200479 DICYCLOMINE HYDROCHLORIDE Muscarinic acetylcholine receptor M3 antagonist 4 DailyMed ISBN
CHEMBL1200604 TROPICAMIDE Muscarinic acetylcholine receptor M3 antagonist 4 ISBN PubMed PubMed
CHEMBL1200764 METHACHOLINE CHLORIDE Muscarinic acetylcholine receptor M3 agonist 4 ISBN PubMed
CHEMBL1200771 TRIDIHEXETHYL CHLORIDE Muscarinic acetylcholine receptor M3 antagonist 4 ISBN PubMed
CHEMBL1200803 SOLIFENACIN SUCCINATE Muscarinic acetylcholine receptor M3 antagonist 4 ISBN PubMed PubMed
CHEMBL1200880 DIPHEMANIL METHYLSULFATE Muscarinic acetylcholine receptor M3 antagonist 4 ISBN PubMed
CHEMBL1200891 OXYPHENCYCLIMINE HYDROCHLORIDE Muscarinic acetylcholine receptor M3 antagonist 4 ISBN PubMed PubMed
CHEMBL1200906 OXYPHENONIUM BROMIDE Muscarinic acetylcholine receptor M3 antagonist 4 ISBN PubMed
CHEMBL1200935 DARIFENACIN HYDROBROMIDE Muscarinic acetylcholine receptor M3 antagonist 4 DailyMed PubMed
CHEMBL1200950 CLIDINIUM BROMIDE Muscarinic acetylcholine receptor M3 antagonist 4 DailyMed DailyMed ISBN
CHEMBL1201024 METHSCOPOLAMINE BROMIDE Muscarinic acetylcholine receptor M3 antagonist 4 DailyMed ISBN
CHEMBL1201027 GLYCOPYRROLATE BROMIDE Muscarinic acetylcholine receptor M3 antagonist 4 DailyMed ISBN PubMed
CHEMBL1201765 FESOTERODINE FUMARATE Muscarinic acetylcholine receptor M3 antagonist 4 DailyMed ISBN PubMed PubMed
CHEMBL1626570 HEXOCYCLIUM METHYLSULFATE Muscarinic acetylcholine receptor M3 antagonist 4 ISBN PubMed PubMed
CHEMBL1722209 TOLTERODINE TARTRATE Muscarinic acetylcholine receptor M3 antagonist 4 DailyMed PubMed
CHEMBL2134724 IPRATROPIUM BROMIDE HYDRATE Muscarinic acetylcholine receptor M3 antagonist 4 DailyMed ISBN PubMed
CHEMBL2146146 ATROPINE SULFATE Muscarinic acetylcholine receptor M3 antagonist 4 FDA ISBN
CHEMBL2218917 CEVIMELINE HYDROCHLORIDE Muscarinic acetylcholine receptor M3 agonist 4 DailyMed ISBN PubMed
CHEMBL3084748 TROSPIUM CHLORIDE Muscarinic acetylcholine receptor M3 antagonist 4 PubMed PubMed
CHEMBL3545181 TIOTROPIUM BROMIDE Muscarinic acetylcholine receptor M3 antagonist 4 DailyMed
CHEMBL1779046 Tarafenacin Muscarinic acetylcholine receptor M3 antagonist 2 PubMed PubMed
CHEMBL3039518 BATEFENTEROL Muscarinic acetylcholine receptor M3 antagonist 2 PubMed PubMed
CHEMBL3545222 AZD8683 Muscarinic acetylcholine receptor M3 antagonist 2 PubMed
CHEMBL3707249 ASM-024 Muscarinic acetylcholine receptor M3 antagonist 2 PubMed PubMed
CHEMBL3545272 LAS190792 Muscarinic acetylcholine receptor M3 antagonist 1 Other Other
More...

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000133019
Ensembl ENSG00000133019
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016323 (basolateral plasma membrane)
GO:0030054 (cell junction)
GO:0030425 (dendrite)
GO:0032279 (asymmetric synapse)
GO:0043679 (axon terminus)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO Molecular Function GO:0004435 (phosphatidylinositol phospholipase C activity)
GO:0004871 (signal transducer activity)
GO:0004872 (receptor activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0005515 (protein binding)
GO:0008144 (drug binding)
GO:0016907 (G-protein coupled acetylcholine receptor activity)
GO:0042166 (acetylcholine binding)
GO Biological Process GO:0003056 (regulation of vascular smooth muscle contraction)
GO:0006464 (cellular protein modification process)
GO:0006939 (smooth muscle contraction)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007197 (adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway)
GO:0007207 (phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway)
GO:0007213 (G-protein coupled acetylcholine receptor signaling pathway)
GO:0007271 (synaptic transmission, cholinergic)
GO:0007399 (nervous system development)
GO:0007586 (digestion)
GO:0008283 (cell proliferation)
GO:0019229 (regulation of vasoconstriction)
GO:0045987 (positive regulation of smooth muscle contraction)
GO:0046541 (saliva secretion)
Wikipedia Muscarinic_acetylcholine_receptor_M3

Target Cross References - Protein

canSAR P20309
CGD Eagle-Barrett syndrome
Human Protein Atlas ENSG00000133019
IntAct P20309
Guide to Pharmacology 15
Open Targets ENSG00000133019
PharmGKB PA112
Pharos P20309 (Tclin)
Reactome R-HSA-390648 (Muscarinic acetylcholine receptors.)
R-HSA-399997 (Acetylcholine regulates insulin secretion.)
R-HSA-416476 (G alpha (q) signalling events.)
UniProt P20309 Q0VAJ8 Q4QRI3 Q5VXY2 Q9HB60

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000995 (Musac_Ach_rcpt.)
IPR001183 (Musac_Ach_M3_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
spacer
spacer