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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2432
Preferred Name Aminopeptidase B
Synonyms AP-B | APB | Aminopeptidase B | Arginine aminopeptidase | Arginyl aminopeptidase | RNPEP
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mae clan > metallo protease m1 family

Target Components

Component Description Relationship Accession
Aminopeptidase B SINGLE PROTEIN Q9H4A4

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3831223 Aminopeptidase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000176393
Ensembl ENSG00000176393
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005886 (plasma membrane)
GO:0030141 (secretory granule)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004177 (aminopeptidase activity)
GO:0004301 (epoxide hydrolase activity)
GO:0008233 (peptidase activity)
GO:0008235 (metalloexopeptidase activity)
GO:0008237 (metallopeptidase activity)
GO:0008270 (zinc ion binding)
GO:0016787 (hydrolase activity)
GO:0042277 (peptide binding)
GO:0046872 (metal ion binding)
GO:0070006 (metalloaminopeptidase activity)
GO Biological Process GO:0006508 (proteolysis)
GO:0043171 (peptide catabolic process)
GO:0045776 (negative regulation of blood pressure)
Wikipedia RNPEP

Target Cross References - Protein

canSAR Q9H4A4
Human Protein Atlas ENSG00000176393
IntAct Q9H4A4
Open Targets ENSG00000176393
PharmGKB PA34451
UniProt Q9BVM9 Q9H1D4 Q9H4A4 Q9NPT7

Target Cross References - Domain

InterPro IPR001930 (Peptidase_M1.)
IPR014782 (Peptidase_M1_N.)
IPR015211 (Peptidase_M1_C.)
IPR015571 (Pept_M1_aminopeptidase-B.)
IPR016024 (ARM-type_fold.)
IPR034015 (M1_LTA4H.)
Pfam PF01433 (Peptidase_M1)
PF09127 (Leuk-A4-hydro_C)