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Target Report Card

Target Name and Classification

Target ID CHEMBL2431
Preferred Name Serine/threonine-protein kinase AKT2
Synonyms AKT2 | PKB beta | Protein kinase Akt-2 | Protein kinase B beta | RAC-PK-beta | RAC-beta serine/threonine-protein kinase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase akt family

Target Components

Component Description Relationship Accession
RAC-beta serine/threonine-protein kinase SINGLE PROTEIN P31751

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111353 Serine/threonine-protein kinase AKT PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3545049 BAY-1125976 Serine/threonine-protein kinase AKT2 inhibitor 1 DOI DOI

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000105221
Ensembl ENSG00000105221
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005768 (endosome)
GO:0005769 (early endosome)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005938 (cell cortex)
GO:0016020 (membrane)
GO:0032587 (ruffle membrane)
GO:0032991 (macromolecular complex)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001934 (positive regulation of protein phosphorylation)
GO:0005975 (carbohydrate metabolic process)
GO:0005977 (glycogen metabolic process)
GO:0005978 (glycogen biosynthetic process)
GO:0006006 (glucose metabolic process)
GO:0006417 (regulation of translation)
GO:0006464 (cellular protein modification process)
GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0007165 (signal transduction)
GO:0007275 (multicellular organism development)
GO:0008284 (positive regulation of cell proliferation)
GO:0008286 (insulin receptor signaling pathway)
GO:0008643 (carbohydrate transport)
GO:0010748 (negative regulation of plasma membrane long-chain fatty acid transport)
GO:0010907 (positive regulation of glucose metabolic process)
GO:0010918 (positive regulation of mitochondrial membrane potential)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0030334 (regulation of cell migration)
GO:0030335 (positive regulation of cell migration)
GO:0031340 (positive regulation of vesicle fusion)
GO:0032000 (positive regulation of fatty acid beta-oxidation)
GO:0032287 (peripheral nervous system myelin maintenance)
GO:0032869 (cellular response to insulin stimulus)
GO:0035556 (intracellular signal transduction)
GO:0043066 (negative regulation of apoptotic process)
GO:0045444 (fat cell differentiation)
GO:0045725 (positive regulation of glycogen biosynthetic process)
GO:0046326 (positive regulation of glucose import)
GO:0060644 (mammary gland epithelial cell differentiation)
GO:0065002 (intracellular protein transmembrane transport)
GO:0071156 (regulation of cell cycle arrest)
GO:0071486 (cellular response to high light intensity)
GO:0072659 (protein localization to plasma membrane)
GO:0090314 (positive regulation of protein targeting to membrane)
GO:0090630 (activation of GTPase activity)
GO:0097473 (retinal rod cell apoptotic process)
GO:2000147 (positive regulation of cell motility)
GO:2001275 (positive regulation of glucose import in response to insulin stimulus)
Wikipedia AKT2

Target Cross References - Protein

canSAR P31751
CGD Hypoinsulinemic hypoglycemia with hemihypertrophy
Human Protein Atlas ENSG00000105221
IntAct P31751
Guide to Pharmacology 1480
Open Targets ENSG00000105221
PharmGKB PA24685
Pharos P31751 (Tchem)
Reactome R-HSA-111447 (Activation of BAD and translocation to mitochondria.)
R-HSA-114604 (GPVI-mediated activation cascade.)
R-HSA-1257604 (PIP3 activates AKT signaling.)
R-HSA-1358803 (Downregulation of ERBB2:ERBB3 signaling.)
R-HSA-1445148 (Translocation of GLUT4 to the plasma membrane.)
R-HSA-165158 (Activation of AKT2.)
R-HSA-165160 (PDE3B signalling.)
R-HSA-165181 (Inhibition of TSC complex formation by PKB.)
R-HSA-198323 (AKT phosphorylates targets in the cytosol.)
R-HSA-198693 (AKT phosphorylates targets in the nucleus.)
R-HSA-199418 (Negative regulation of the PI3K/AKT network.)
R-HSA-211163 (AKT-mediated inactivation of FOXO1A.)
R-HSA-3769402 (Deactivation of the beta-catenin transactivating complex.)
R-HSA-389357 (CD28 dependent PI3K/Akt signaling.)
R-HSA-389513 (CTLA4 inhibitory signaling.)
R-HSA-392451 (G beta:gamma signalling through PI3Kgamma.)
R-HSA-5218920 (VEGFR2 mediated vascular permeability.)
R-HSA-5628897 (TP53 Regulates Metabolic Genes.)
R-HSA-5674400 (Constitutive Signaling by AKT1 E17K in Cancer.)
R-HSA-6804757 (Regulation of TP53 Degradation.)
R-HSA-6804758 (Regulation of TP53 Activity through Acetylation.)
R-HSA-6804759 (Regulation of TP53 Activity through Association with Co-factors.)
R-HSA-69202 (Cyclin E associated events during G1/S transition.)
R-HSA-8876198 (RAB GEFs exchange GTP for GDP on RABs.)
R-HSA-8941332 (RUNX2 regulates genes involved in cell migration.)
R-HSA-8948751 (Regulation of PTEN stability and activity.)
UniProt B2RBD8 P31751 Q05BV0 Q0VAN0 Q0VAN1 Q68GC0

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR000961 (AGC-kinase_C.)
IPR001849 (PH_domain.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR011993 (PH-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017892 (Pkinase_C.)
IPR034677 (Akt2.)
Pfam PF00069 (Pkinase)
PF00169 (PH)
PF00433 (Pkinase_C)

Target Cross References - Structure

PDBe 1GZK 1GZN 1GZO 1MRV 1MRY 1O6K 1O6L 2JDO 2JDR 2UW9 2X39 2XH5 3D0E 3E87 3E88 3E8D
CREDO 1GZK 1GZN 1GZO 1MRV 1MRY 1O6K 1O6L 2JDO 2JDR 2UW9 2X39 2XH5 3D0E 3E87 3E88 3E8D