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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2425
Target Type SINGLE PROTEIN
Preferred Name Dihydrofolate reductase
Synonyms Bifunctional dihydrofolate reductase-thymidylate synthase | DHFR-TS | Dihydrofolate reductase | Thymidylate synthase
Organism Toxoplasma gondii
Species Group No
Protein Target Classification
  • enzyme > oxidoreductase

Target Components

Component Description Relationship Accession
Bifunctional dihydrofolate reductase-thymidylate synthase SINGLE PROTEIN Q07422

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2097172 Dihydrofolate reductase; T. gondii vs rat SELECTIVITY GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Molecular Function GO:0003824 (catalytic activity)
GO:0004146 (dihydrofolate reductase activity)
GO:0004799 (thymidylate synthase activity)
GO:0008168 (methyltransferase activity)
GO:0016491 (oxidoreductase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0006231 (dTMP biosynthetic process)
GO:0006730 (one-carbon metabolic process)
GO:0008152 (metabolic process)
GO:0009165 (nucleotide biosynthetic process)
GO:0032259 (methylation)
GO:0046654 (tetrahydrofolate biosynthetic process)
GO:0055114 (oxidation-reduction process)

Target Cross References - Protein

canSAR Q07422
UniProt Q07422

Target Cross References - Domain

InterPro IPR000398 (Thymidylate_synthase.)
IPR001796 (DHFR_dom.)
IPR012262 (DHFR-TS.)
IPR017925 (DHFR_CS.)
IPR020940 (Thymidylate_synthase_AS.)
IPR023451 (Thymidate_synth/dCMP_Mease.)
IPR024072 (DHFR-like_dom_sf.)
IPR036926 (Thymidate_synth/dCMP_Mease_sf.)
Pfam PF00186 (DHFR_1)
PF00303 (Thymidylat_synt)

Target Cross References - Structure

PDBe 4ECK 4EIL 4KY4 4KYA 5T0L
CREDO 4ECK 4EIL 4KY4 4KYA 5T0L
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