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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL241
Target Type SINGLE PROTEIN
Preferred Name Phosphodiesterase 3A
Synonyms CGI-PDE A | Cyclic GMP-inhibited phosphodiesterase A | PDE3A | cGMP-inhibited 3',5'-cyclic phosphodiesterase A
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > phosphodiesterase > phosphodiesterase 3 > phosphodiesterase 3a

Target Components

Component Description Relationship Accession
cGMP-inhibited 3',5'-cyclic phosphodiesterase A SINGLE PROTEIN Q14432

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363066 3',5'-cyclic phosphodiesterase PROTEIN FAMILY
CHEMBL2094125 Phosphodiesterase 3 PROTEIN FAMILY
CHEMBL2095153 Phosphodiesterase; PDE3 & PDE4 SELECTIVITY GROUP
CHEMBL2111400 Phosphodiesterase 3 and 5 (PDE3 and PDE5) SELECTIVITY GROUP

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL799 CILOSTAZOL Phosphodiesterase 3A inhibitor 4 DailyMed
CHEMBL1752 DYPHYLLINE Phosphodiesterase 3A inhibitor 4 DailyMed PubMed
CHEMBL1200977 MILRINONE LACTATE Phosphodiesterase 3A inhibitor 4 FDA
CHEMBL2096642 INAMRINONE LACTATE Phosphodiesterase 3A inhibitor 4 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000172572
Ensembl ENSG00000172572
GO Cellular Component GO:0005829 (cytosol)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004114 (3',5'-cyclic-nucleotide phosphodiesterase activity)
GO:0004115 (3',5'-cyclic-AMP phosphodiesterase activity)
GO:0004119 (cGMP-inhibited cyclic-nucleotide phosphodiesterase activity)
GO:0005515 (protein binding)
GO:0008081 (phosphoric diester hydrolase activity)
GO:0016787 (hydrolase activity)
GO:0030552 (cAMP binding)
GO:0046872 (metal ion binding)
GO:0047555 (3',5'-cyclic-GMP phosphodiesterase activity)
GO Biological Process GO:0001556 (oocyte maturation)
GO:0006198 (cAMP catabolic process)
GO:0006629 (lipid metabolic process)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0016101 (diterpenoid metabolic process)
GO:0019933 (cAMP-mediated signaling)
GO:0019934 (cGMP-mediated signaling)
GO:0040020 (regulation of meiotic nuclear division)
GO:0042493 (response to drug)
GO:0043066 (negative regulation of apoptotic process)
GO:0043116 (negative regulation of vascular permeability)
GO:0043117 (positive regulation of vascular permeability)
GO:0051591 (response to cAMP)
GO:0060282 (positive regulation of oocyte development)
GO:0071321 (cellular response to cGMP)
GO:0071560 (cellular response to transforming growth factor beta stimulus)

Target Cross References - Protein

canSAR Q14432
Human Protein Atlas ENSG00000172572
IntAct Q14432
Guide to Pharmacology 1298
Open Targets ENSG00000172572
PharmGKB PA33126
Reactome R-HSA-418457 (cGMP effects.)
R-HSA-418555 (G alpha (s) signalling events.)
UniProt O60865 Q13348 Q14432 Q17RD1

Target Cross References - Domain

InterPro IPR002073 (PDEase_catalytic_dom.)
IPR003607 (HD/PDEase_dom.)
IPR023174 (PDEase_CS.)
IPR036971 (PDEase_catalytic_dom_sf.)
Pfam PF00233 (PDEase_I)
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