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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2397
Preferred Name Acetyl-CoA carboxylase 1
Synonyms ACC-alpha | ACC1 | Acac | Acaca | Acetyl-CoA carboxylase 1 | Biotin carboxylase
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Acetyl-CoA carboxylase 1 SINGLE PROTEIN P11497

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3885506 Acetyl-CoA carboxylase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003824 (catalytic activity)
GO:0003989 (acetyl-CoA carboxylase activity)
GO:0004075 (biotin carboxylase activity)
GO:0005524 (ATP binding)
GO:0009374 (biotin binding)
GO:0016874 (ligase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006084 (acetyl-CoA metabolic process)
GO:0006629 (lipid metabolic process)
GO:0006631 (fatty acid metabolic process)
GO:0006633 (fatty acid biosynthetic process)
GO:0008152 (metabolic process)
GO:0014070 (response to organic cyclic compound)
GO:0042493 (response to drug)
GO:0051289 (protein homotetramerization)
GO:2001295 (malonyl-CoA biosynthetic process)

Target Cross References - Protein

canSAR P11497
UniProt A1EC79 P11497 P97902

Target Cross References - Domain

InterPro IPR000089 (Biotin_lipoyl.)
IPR001882 (Biotin_BS.)
IPR005479 (CbamoylP_synth_lsu-like_ATP-bd.)
IPR005481 (BC-like_N.)
IPR005482 (Biotin_COase_C.)
IPR011053 (Single_hybrid_motif.)
IPR011054 (Rudment_hybrid_motif.)
IPR011761 (ATP-grasp.)
IPR011762 (COA_CT_N.)
IPR011763 (COA_CT_C.)
IPR011764 (Biotin_carboxylation_dom.)
IPR013537 (AcCoA_COase_cen.)
IPR013815 (ATP_grasp_subdomain_1.)
IPR016185 (PreATP-grasp_dom_sf.)
IPR029045 (ClpP/crotonase-like_dom_sf.)
IPR034733 (AcCoA_carboxyl.)
Pfam PF00289 (Biotin_carb_N)
PF00364 (Biotin_lipoyl)
PF01039 (Carboxyl_trans)
PF02785 (Biotin_carb_C)
PF02786 (CPSase_L_D2)
PF08326 (ACC_central)