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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2393
Target Type SINGLE PROTEIN
Preferred Name AMP-activated protein kinase, gamma-1 subunit
Synonyms 5'-AMP-activated protein kinase subunit gamma-1 | AMPK gamma1 | AMPK subunit gamma-1 | AMPKg | PRKAG1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase regulatory subunit

Target Components

Component Description Relationship Accession
5'-AMP-activated protein kinase subunit gamma-1 SINGLE PROTEIN P54619

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111345 AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 PROTEIN COMPLEX
CHEMBL3038453 AMPK alpha1/beta2/gamma1 PROTEIN COMPLEX
CHEMBL3038455 AMPK alpha2/beta1/gamma1 PROTEIN COMPLEX
CHEMBL3038456 AMPK alpha2/beta2/gamma1 PROTEIN COMPLEX
CHEMBL2096907 AMP-activated protein kinase, AMPK PROTEIN COMPLEX GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000181929
Ensembl ENSG00000181929
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005829 (cytosol)
GO:0016020 (membrane)
GO:0031588 (nucleotide-activated protein kinase complex)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004679 (AMP-activated protein kinase activity)
GO:0004691 (cAMP-dependent protein kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008603 (cAMP-dependent protein kinase regulator activity)
GO:0016208 (AMP binding)
GO:0019901 (protein kinase binding)
GO:0043531 (ADP binding)
GO Biological Process GO:0006110 (regulation of glycolytic process)
GO:0006468 (protein phosphorylation)
GO:0006629 (lipid metabolic process)
GO:0006631 (fatty acid metabolic process)
GO:0006633 (fatty acid biosynthetic process)
GO:0007050 (cell cycle arrest)
GO:0007165 (signal transduction)
GO:0007283 (spermatogenesis)
GO:0010628 (positive regulation of gene expression)
GO:0016236 (macroautophagy)
GO:0045860 (positive regulation of protein kinase activity)
GO:1901796 (regulation of signal transduction by p53 class mediator)
Wikipedia PRKAG1

Target Cross References - Protein

canSAR P54619
Human Protein Atlas ENSG00000181929
IntAct P54619
Open Targets ENSG00000181929
PharmGKB PA33751
Pharos P54619 (Tbio)
Reactome R-HSA-1445148 (Translocation of GLUT4 to the plasma membrane.)
R-HSA-1632852 (Macroautophagy.)
R-HSA-2151209 (Activation of PPARGC1A (PGC-1alpha) by phosphorylation.)
R-HSA-380972 (Energy dependent regulation of mTOR by LKB1-AMPK.)
R-HSA-5628897 (TP53 Regulates Metabolic Genes.)
R-HSA-6804756 (Regulation of TP53 Activity through Phosphorylation.)
UniProt B4DDT7 P54619 Q8N7V9

Target Cross References - Domain

InterPro IPR000644 (CBS_dom.)
Pfam PF00571 (CBS)

Target Cross References - Structure

PDBe 2UV4 2UV5 2UV6 2UV7 4CFE 4CFF 4RER 4REW 4ZHX 5EZV
CREDO 2UV4 2UV5 2UV6 2UV7 4CFE 4CFF 4RER 4REW 4ZHX 5EZV
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