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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2370
Preferred Name Norepinephrine transporter
Synonyms NET | Norepinephrine transporter | Slc6a2 | Sodium-dependent noradrenaline transporter | Solute carrier family 6 member 2
Organism Mus musculus
Species Group No
Protein Target Classification
  • transporter > electrochemical transporter > slc superfamily of solute carriers > slc06 neurotransmitter transporter family

Target Components

Component Description Relationship Accession
Sodium-dependent noradrenaline transporter SINGLE PROTEIN O55192

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043005 (neuron projection)
GO:0045121 (membrane raft)
GO Molecular Function GO:0005328 (neurotransmitter:sodium symporter activity)
GO:0005330 (dopamine:sodium symporter activity)
GO:0005333 (norepinephrine transmembrane transporter activity)
GO:0008504 (monoamine transmembrane transporter activity)
GO:0015293 (symporter activity)
GO:0043014 (alpha-tubulin binding)
GO:0046872 (metal ion binding)
GO:0048487 (beta-tubulin binding)
GO Biological Process GO:0006836 (neurotransmitter transport)
GO:0015844 (monoamine transport)
GO:0015874 (norepinephrine transport)
GO:0042493 (response to drug)
GO:0048265 (response to pain)
GO:0051583 (dopamine uptake involved in synaptic transmission)
GO:0055085 (transmembrane transport)

Target Cross References - Protein

MICAD NBK22978 (Brain norepinephrine transporter (NET))
NBK23167 (Norepinephrine transporter (NET))
NBK23205 (Brain norepinephrine transporter (NET))
NBK23527 (Brain norepinephrine transporter (NET))
Reactome R-MMU-442660 (Na+/Cl- dependent neurotransmitter transporters.)
UniProt O55192 Q6QU62

Target Cross References - Domain

InterPro IPR000175 (Na/ntran_symport.)
IPR002435 (Na/ntran_symport_noradrenaline.)
IPR037272 (SNS_sf.)
Pfam PF00209 (SNF)