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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2363065
Target Type PROTEIN COMPLEX
Preferred Name Mitochondrial complex I (NADH dehydrogenase)
Synonyms
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > oxidoreductase

Target Components

Component Description Relationship Accession
NADH-ubiquinone oxidoreductase chain 6 PROTEIN SUBUNIT P03923
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial PROTEIN SUBUNIT O95299
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial PROTEIN SUBUNIT O00217
NADH-ubiquinone oxidoreductase chain 4L PROTEIN SUBUNIT P03901
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 PROTEIN SUBUNIT P56556
NADH-ubiquinone oxidoreductase chain 1 PROTEIN SUBUNIT P03886
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 PROTEIN SUBUNIT O95139
Cytochrome c oxidase subunit NDUFA4 PROTEIN SUBUNIT O00483
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 PROTEIN SUBUNIT Q86Y39
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 PROTEIN SUBUNIT P17568
NADH-ubiquinone oxidoreductase chain 2 PROTEIN SUBUNIT P03891
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial PROTEIN SUBUNIT O75306
NADH-ubiquinone oxidoreductase chain 5 PROTEIN SUBUNIT P03915
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 PROTEIN SUBUNIT P51970
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial PROTEIN SUBUNIT O43674
NADH-ubiquinone oxidoreductase chain 4 PROTEIN SUBUNIT P03905
NADH-ubiquinone oxidoreductase chain 3 PROTEIN SUBUNIT P03897
Acyl carrier protein, mitochondrial PROTEIN SUBUNIT O14561
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 PROTEIN SUBUNIT O15239
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial PROTEIN SUBUNIT O43181
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 PROTEIN SUBUNIT O43676
NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial PROTEIN SUBUNIT O43677
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 PROTEIN SUBUNIT O43678
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 PROTEIN SUBUNIT O43920
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial PROTEIN SUBUNIT O75251
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial PROTEIN SUBUNIT O75380
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 PROTEIN SUBUNIT O75438
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial PROTEIN SUBUNIT O75489
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 PROTEIN SUBUNIT O95167
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 PROTEIN SUBUNIT O95168
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial PROTEIN SUBUNIT O95169
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial PROTEIN SUBUNIT O95178
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 PROTEIN SUBUNIT O95182
NADH dehydrogenase [ubiquinone] 1 subunit C2 PROTEIN SUBUNIT O95298
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 PROTEIN SUBUNIT O96000
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial PROTEIN SUBUNIT P19404
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial PROTEIN SUBUNIT P28331
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial PROTEIN SUBUNIT P49821
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial PROTEIN SUBUNIT P56181
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 PROTEIN SUBUNIT Q16718
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial PROTEIN SUBUNIT Q16795
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 PROTEIN SUBUNIT Q8N183
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 PROTEIN SUBUNIT Q9BU61
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 PROTEIN SUBUNIT Q9NRX3
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial PROTEIN SUBUNIT Q9NX14
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 PROTEIN SUBUNIT Q9P032
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 PROTEIN SUBUNIT Q9P0J0
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 PROTEIN SUBUNIT Q9UI09
Complex I intermediate-associated protein 30, mitochondrial PROTEIN SUBUNIT Q9Y375
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 PROTEIN SUBUNIT Q9Y6M9

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL4499 NADH-ubiquinone oxidoreductase chain 4 SINGLE PROTEIN
CHEMBL2317 NADH-ubiquinone oxidoreductase MLRQ subunit SINGLE PROTEIN

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1703 METFORMIN HYDROCHLORIDE Mitochondrial complex I (NADH dehydrogenase) inhibitor 4 PubMed PubMed PubMed
CHEMBL3545135 NV-128 Mitochondrial complex I (NADH dehydrogenase) inhibitor 1 Other PubMed PubMed
CHEMBL3545320 ME-344 Mitochondrial complex I (NADH dehydrogenase) inhibitor 1 Other PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

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