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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2363049
Target Type PROTEIN FAMILY
Preferred Name Epidermal growth factor receptor
Synonyms 4ICD | CD_antigen=CD340 | E4ICD | EGFR | ERBB | ERBB1 | ERBB2 | ERBB3 | ERBB4 intracellular domain | ERBB4 | Epidermal growth factor receptor | HER1 | HER2 | HER3 | HER4 | MLN 19 | MLN19 | Metastatic lymph node gene 19 protein | NEU | NGL | Proto-oncogene Neu | Proto-oncogene c-ErbB-1 | Proto-oncogene c-ErbB-2 | Proto-oncogene-like protein c-ErbB-3 | Proto-oncogene-like protein c-ErbB-4 | Receptor tyrosine-protein kinase erbB-1 | Receptor tyrosine-protein kinase erbB-2 | Receptor tyrosine-protein kinase erbB-3 | Receptor tyrosine-protein kinase erbB-4 | Tyrosine kinase-type cell surface receptor HER2 | Tyrosine kinase-type cell surface receptor HER3 | Tyrosine kinase-type cell surface receptor HER4 | p180erbB4 | p185erbB2 | s80HER4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase egfr family

Target Components

Component Description Relationship Accession
Epidermal growth factor receptor GROUP MEMBER P00533
Receptor tyrosine-protein kinase erbB-2 GROUP MEMBER P04626
Receptor tyrosine-protein kinase erbB-3 GROUP MEMBER P21860
Receptor tyrosine-protein kinase erbB-4 GROUP MEMBER Q15303

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL5838 Receptor tyrosine-protein kinase erbB-3 SINGLE PROTEIN
CHEMBL203 Epidermal growth factor receptor erbB1 SINGLE PROTEIN
CHEMBL3009 Receptor protein-tyrosine kinase erbB-4 SINGLE PROTEIN
CHEMBL1824 Receptor protein-tyrosine kinase erbB-2 SINGLE PROTEIN
CHEMBL3137284 MER intracellular domain/EGFR extracellular domain chimera CHIMERIC PROTEIN
CHEMBL2111431 Epidermal growth factor receptor and ErbB2 (HER1 and HER2) PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL24828 VANDETANIB Epidermal growth factor receptor inhibitor 4 DailyMed
CHEMBL3545063 OSIMERTINIB MESYLATE Epidermal growth factor receptor inhibitor 4 DailyMed
CHEMBL2110732 DACOMITINIB Epidermal growth factor receptor inhibitor 3 Other PubMed
CHEMBL3545154 Poziotinib Epidermal growth factor receptor inhibitor 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

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