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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2359
Target Type SINGLE PROTEIN
Preferred Name CaM kinase II alpha
Synonyms CaM kinase II subunit alpha | CaMK-II subunit alpha | Calcium/calmodulin-dependent protein kinase type II subunit alpha | Camk2a
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > camk protein kinase group > camk protein kinase camk2 family

Target Components

Component Description Relationship Accession
Calcium/calmodulin-dependent protein kinase type II subunit alpha SINGLE PROTEIN P11275

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111382 Ca2+/calmodulin-dependent protein kinase II (CaM kinase II) PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005634 (nucleus)
GO:0005739 (mitochondrion)
GO:0005886 (plasma membrane)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0030054 (cell junction)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0032839 (dendrite cytoplasm)
GO:0042734 (presynaptic membrane)
GO:0043025 (neuronal cell body)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO:0099524 (postsynaptic cytosol)
GO:0099573 (glutamatergic postsynaptic density)
GO:0099634 (postsynaptic specialization membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004683 (calmodulin-dependent protein kinase activity)
GO:0005515 (protein binding)
GO:0005516 (calmodulin binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0032794 (GTPase activating protein binding)
GO:0035254 (glutamate receptor binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0000082 (G1/S transition of mitotic cell cycle)
GO:0002931 (response to ischemia)
GO:0006468 (protein phosphorylation)
GO:0006816 (calcium ion transport)
GO:0007399 (nervous system development)
GO:0010666 (positive regulation of cardiac muscle cell apoptotic process)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0018107 (peptidyl-threonine phosphorylation)
GO:0030154 (cell differentiation)
GO:0035235 (ionotropic glutamate receptor signaling pathway)
GO:0035556 (intracellular signal transduction)
GO:0046777 (protein autophosphorylation)
GO:0046928 (regulation of neurotransmitter secretion)
GO:0048168 (regulation of neuronal synaptic plasticity)
GO:0051928 (positive regulation of calcium ion transport)
GO:0098970 (postsynaptic neurotransmitter receptor diffusion trapping)
GO:0098989 (NMDA selective glutamate receptor signaling pathway)
GO:0099004 (calmodulin dependent kinase signaling pathway)
GO:1902108 (regulation of mitochondrial membrane permeability involved in apoptotic process)
GO:1903076 (regulation of protein localization to plasma membrane)

Target Cross References - Protein

canSAR P11275
IntAct P11275
Guide to Pharmacology 1555
UniProt P11275

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR013543 (Ca/CaM-dep_prot_kinase-assoc.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR032710 (NTF2-like_dom_sf.)
Pfam PF00069 (Pkinase)
PF08332 (CaMKII_AD)

Target Cross References - Structure

PDBe 1CDM 1CM1 1CM4
CREDO 1CDM 1CM1 1CM4
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