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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2358
Target Type SINGLE PROTEIN
Preferred Name Casein kinase II beta
Synonyms CK II beta | CK2N | CSNK2B | Casein kinase II subunit beta | G5A | Phosvitin | Protein G5a
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase regulatory subunit

Target Components

Component Description Relationship Accession
Casein kinase II subunit beta SINGLE PROTEIN P67870

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3883328 Casein kinase II alpha'/ beta PROTEIN COMPLEX
CHEMBL3832943 Casein kinase 2 PROTEIN FAMILY
CHEMBL2095191 Casein kinase II PROTEIN COMPLEX GROUP
CHEMBL3885539 Casein kinase I isoform alpha/subunit beta PROTEIN COMPLEX
CHEMBL3038477 Casein kinase II alpha/beta PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000204435 ENSG00000206406 ENSG00000224398 ENSG00000224774 ENSG00000228875 ENSG00000230700 ENSG00000232960
Ensembl ENSG00000204435 ENSG00000206406 ENSG00000224398 ENSG00000224774 ENSG00000228875 ENSG00000230700 ENSG00000232960
GO Cellular Component GO:0000785 (chromatin)
GO:0005576 (extracellular region)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005929 (cilium)
GO:0005956 (protein kinase CK2 complex)
GO:0016363 (nuclear matrix)
GO:0031519 (PcG protein complex)
GO:0034774 (secretory granule lumen)
GO:0042995 (cell projection)
GO:0070062 (extracellular exosome)
GO:1904813 (ficolin-1-rich granule lumen)
GO Molecular Function GO:0003682 (chromatin binding)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005102 (receptor binding)
GO:0005515 (protein binding)
GO:0008134 (transcription factor binding)
GO:0019887 (protein kinase regulator activity)
GO:0019904 (protein domain specific binding)
GO:0042802 (identical protein binding)
GO:0043021 (ribonucleoprotein complex binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006457 (protein folding)
GO:0006656 (phosphatidylcholine biosynthetic process)
GO:0007165 (signal transduction)
GO:0008285 (negative regulation of cell proliferation)
GO:0010862 (positive regulation of pathway-restricted SMAD protein phosphorylation)
GO:0016055 (Wnt signaling pathway)
GO:0016236 (macroautophagy)
GO:0018107 (peptidyl-threonine phosphorylation)
GO:0032927 (positive regulation of activin receptor signaling pathway)
GO:0033211 (adiponectin-activated signaling pathway)
GO:0033574 (response to testosterone)
GO:0034622 (cellular protein-containing complex assembly)
GO:0043312 (neutrophil degranulation)
GO:0043537 (negative regulation of blood vessel endothelial cell migration)
GO:0045859 (regulation of protein kinase activity)
GO:0051101 (regulation of DNA binding)
GO:0061154 (endothelial tube morphogenesis)
GO:0097421 (liver regeneration)
GO:1901796 (regulation of signal transduction by p53 class mediator)
Wikipedia CSNK2B

Target Cross References - Protein

canSAR P67870
Human Protein Atlas ENSG00000204435 ENSG00000206406 ENSG00000224398 ENSG00000224774 ENSG00000228875 ENSG00000230700 ENSG00000232960
IntAct P67870
Open Targets ENSG00000204435 ENSG00000206406 ENSG00000224398 ENSG00000224774 ENSG00000228875 ENSG00000230700 ENSG00000232960
PharmGKB PA26960
Pharos P67870 (Tbio)
Reactome R-HSA-1483191 (Synthesis of PC.)
R-HSA-201688 (WNT mediated activation of DVL.)
R-HSA-2514853 (Condensation of Prometaphase Chromosomes.)
R-HSA-445144 (Signal transduction by L1.)
R-HSA-6798695 (Neutrophil degranulation.)
R-HSA-6804756 (Regulation of TP53 Activity through Phosphorylation.)
R-HSA-6814122 (Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.)
R-HSA-8934903 (Receptor Mediated Mitophagy.)
R-HSA-8939243 (RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known.)
R-HSA-8948751 (Regulation of PTEN stability and activity.)
UniProt B0UXA9 P07312 P13862 P67870 Q4VX47

Target Cross References - Domain

InterPro IPR000704 (Casein_kinase_II_reg-sub.)
IPR016149 (Casein_kin_II_reg-sub_N.)
IPR035991 (Casein_kinase_II_beta_like.)
Pfam PF01214 (CK_II_beta)

Target Cross References - Structure

PDBe 1DS5 1JWH 1QF8 3EED 4DGL 4MD7 4MD8 4MD9 4NH1
CREDO 1DS5 1JWH 1QF8 3EED 4DGL 4MD7 4MD8 4MD9 4NH1
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