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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2350
Target Type SINGLE PROTEIN
Preferred Name Alpha-2a adrenergic receptor
Synonyms A2AR | ADRA2A | Alpha-2A adrenergic receptor | Alpha-2A adrenoceptor | Alpha-2A adrenoreceptor | Alpha-2AAR
Organism Sus scrofa
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > adrenergic receptor

Target Components

Component Description Relationship Accession
Alpha-2A adrenergic receptor SINGLE PROTEIN P18871

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005622 (intracellular)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004935 (adrenergic receptor activity)
GO:0004938 (alpha2-adrenergic receptor activity)
GO:0031692 (alpha-1B adrenergic receptor binding)
GO:0046982 (protein heterodimerization activity)
GO:0051379 (epinephrine binding)
GO Biological Process GO:0006940 (regulation of smooth muscle contraction)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007193 (adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway)
GO:0007267 (cell-cell signaling)
GO:0019229 (regulation of vasoconstriction)
GO:0030168 (platelet activation)
GO:0043268 (positive regulation of potassium ion transport)
GO:0051926 (negative regulation of calcium ion transport)
GO:0071878 (negative regulation of adrenergic receptor signaling pathway)
GO:0071880 (adenylate cyclase-activating adrenergic receptor signaling pathway)
GO:0106072 (negative regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:1901020 (negative regulation of calcium ion transmembrane transporter activity)

Target Cross References - Protein

canSAR P18871
Reactome R-SSC-390696 (Adrenoceptors.)
R-SSC-392023 (Adrenaline signalling through Alpha-2 adrenergic receptor.)
R-SSC-400042 (Adrenaline,noradrenaline inhibits insulin secretion.)
R-SSC-418594 (G alpha (i) signalling events.)
R-SSC-418597 (G alpha (z) signalling events.)
R-SSC-5683826 (Surfactant metabolism.)
UniProt P18871

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR001946 (ADRA2A_rcpt.)
IPR002233 (ADR_fam.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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