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Target Report Card

Target Name and Classification

Target ID CHEMBL2345
Preferred Name Ribosomal protein S6 kinase alpha 3
Synonyms 90 kDa ribosomal protein S6 kinase 3 | ISPK-1 | ISPK1 | Insulin-stimulated protein kinase 1 | MAP kinase-activated protein kinase 1b | MAPK-activated protein kinase 1b | MAPKAP kinase 1b | MAPKAPK-1b | MAPKAPK1B | RPS6KA3 | RSK-2 | RSK2 | Ribosomal S6 kinase 2 | Ribosomal protein S6 kinase alpha-3 | S6K-alpha-3 | p90-RSK 3 | p90RSK3 | pp90RSK2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > camk protein kinase group > camk protein kinase rskb family > camk protein kinase rskb subfamily
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase rsk family > agc protein kinase rsk subfamily

Target Components

Component Description Relationship Accession
Ribosomal protein S6 kinase alpha-3 SINGLE PROTEIN P51812

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3832633 Ribosomal protein S6 kinase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000177189
Ensembl ENSG00000177189
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000287 (magnesium ion binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0043027 (cysteine-type endopeptidase inhibitor activity involved in apoptotic process)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001501 (skeletal system development)
GO:0002224 (toll-like receptor signaling pathway)
GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0007049 (cell cycle)
GO:0007165 (signal transduction)
GO:0007417 (central nervous system development)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0030307 (positive regulation of cell growth)
GO:0032496 (response to lipopolysaccharide)
GO:0035556 (intracellular signal transduction)
GO:0043066 (negative regulation of apoptotic process)
GO:0043154 (negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0043555 (regulation of translation in response to stress)
GO:0043620 (regulation of DNA-templated transcription in response to stress)
GO:0045597 (positive regulation of cell differentiation)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
Wikipedia RPS6KA3

Target Cross References - Protein

canSAR P51812
CGD Coffin-Lowry syndrome; Mental retardation, X-linked 19
Human Protein Atlas ENSG00000177189
IntAct P51812
Guide to Pharmacology 1528
Open Targets ENSG00000177189
PharmGKB PA34847
Pharos P51812 (Tchem)
Reactome R-HSA-198753 (ERK/MAPK targets.)
R-HSA-199920 (CREB phosphorylation.)
R-HSA-2559582 (Senescence-Associated Secretory Phenotype (SASP).)
R-HSA-437239 (Recycling pathway of L1.)
R-HSA-442742 (CREB phosphorylation through the activation of Ras.)
R-HSA-444257 (RSK activation.)
R-HSA-881907 (Gastrin-CREB signalling pathway via PKC and MAPK.)
UniProt B2R9V4 P51812 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR000961 (AGC-kinase_C.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR016239 (Ribosomal_S6_kinase_II.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017892 (Pkinase_C.)
Pfam PF00069 (Pkinase)
PF00433 (Pkinase_C)

Target Cross References - Structure

PDBe 4D9T 4D9U 4JG6 4JG7 4JG8 4NUS 4NW5 4NW6 5D9K 5D9L
CREDO 4D9T 4D9U 4JG6 4JG7 4JG8 4NUS 4NW5 4NW6 5D9K 5D9L