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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2344
Target Type SINGLE PROTEIN
Preferred Name Vasopressin V2 receptor
Synonyms AVPR V2 | AVPR2 | Antidiuretic hormone receptor | Renal-type arginine vasopressin receptor | V2R | Vasopressin V2 receptor
Organism Bos taurus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > short peptide receptor (family a gpcr) > vasopressin and oxytocin receptor

Target Components

Component Description Relationship Accession
Vasopressin V2 receptor SINGLE PROTEIN P48044

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005622 (intracellular)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0005000 (vasopressin receptor activity)
GO:0042277 (peptide binding)
GO Biological Process GO:0001992 (regulation of systemic arterial blood pressure by vasopressin)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007249 (I-kappaB kinase/NF-kappaB signaling)
GO:0010628 (positive regulation of gene expression)
GO:0032609 (interferon-gamma production)
GO:0032870 (cellular response to hormone stimulus)
GO:0034097 (response to cytokine)
GO:0045907 (positive regulation of vasoconstriction)
GO:1901652 (response to peptide)

Target Cross References - Protein

canSAR P48044
Reactome R-BTA-388479 (Vasopressin-like receptors.)
R-BTA-418555 (G alpha (s) signalling events.)
R-BTA-432040 (Vasopressin regulates renal water homeostasis via Aquaporins.)
R-BTA-8856825 (Cargo recognition for clathrin-mediated endocytosis.)
R-BTA-8856828 (Clathrin-mediated endocytosis.)
UniProt P48044

Target Cross References - Domain

InterPro IPR000161 (Vprsn_rcpt_V2.)
IPR000276 (GPCR_Rhodpsn.)
IPR001817 (Vasoprsn_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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