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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2339
Target Type SINGLE PROTEIN
Preferred Name Cytochrome P450 7A1
Synonyms CYPVII | Cholesterol 7-alpha-hydroxylase | Cholesterol 7-alpha-monooxygenase | Cyp7 | Cyp7a1 | Cytochrome P450 7A1
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • enzyme > cytochrome p450 > cytochrome p450 family 7 > cytochrome p450 family 7a > cytochrome p450 7a1

Target Components

Component Description Relationship Accession
Cholesterol 7-alpha-monooxygenase SINGLE PROTEIN P18125

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016020 (membrane)
GO:0031090 (organelle membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0004497 (monooxygenase activity)
GO:0005506 (iron ion binding)
GO:0008123 (cholesterol 7-alpha-monooxygenase activity)
GO:0016491 (oxidoreductase activity)
GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
GO:0020037 (heme binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006629 (lipid metabolic process)
GO:0006699 (bile acid biosynthetic process)
GO:0006707 (cholesterol catabolic process)
GO:0008202 (steroid metabolic process)
GO:0008203 (cholesterol metabolic process)
GO:0042632 (cholesterol homeostasis)
GO:0055114 (oxidation-reduction process)
GO:0070857 (regulation of bile acid biosynthetic process)
GO:0071333 (cellular response to glucose stimulus)
GO:0071397 (cellular response to cholesterol)

Target Cross References - Protein

canSAR P18125
Reactome R-RNO-192105 (Synthesis of bile acids and bile salts.)
R-RNO-193368 (Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.)
R-RNO-193807 (Synthesis of bile acids and bile salts via 27-hydroxycholesterol.)
R-RNO-211976 (Endogenous sterols.)
UniProt P18125 P51543

Target Cross References - Domain

InterPro IPR001128 (Cyt_P450.)
IPR002403 (Cyt_P450_E_grp-IV.)
IPR017972 (Cyt_P450_CS.)
IPR024204 (Cyt_P450_CYP7A1-type.)
IPR030681 (Cholesterol_7a_monooxygenase.)
IPR036396 (Cyt_P450_sf.)
Pfam PF00067 (p450)
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