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Target Report Card

Target Name and Classification

Target ID CHEMBL2336
Preferred Name MAP kinase p38 alpha
Synonyms CRK1 | Crk1 | Csbp1 | Csbp2 | MAP kinase 14 | MAP kinase p38 alpha | MAPK 14 | Mapk14 | Mitogen-activated protein kinase 14 | Mitogen-activated protein kinase p38 alpha
Organism Mus musculus
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > cmgc protein kinase group > cmgc protein kinase mapk family > cmgc protein kinase p38 subfamily

Target Components

Component Description Relationship Accession
Mitogen-activated protein kinase 14 SINGLE PROTEIN P47811

Target Relations

ChEMBL ID Pref Name Target Type

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0000922 (spindle pole)
GO:0005623 (cell)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005829 (cytosol)
GO:0016607 (nuclear speck)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004707 (MAP kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008022 (protein C-terminus binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019899 (enzyme binding)
GO:0019903 (protein phosphatase binding)
GO:0048273 (mitogen-activated protein kinase p38 binding)
GO:0051525 (NFAT protein binding)
GO Biological Process GO:0000077 (DNA damage checkpoint)
GO:0000902 (cell morphogenesis)
GO:0001502 (cartilage condensation)
GO:0001525 (angiogenesis)
GO:0001890 (placenta development)
GO:0002062 (chondrocyte differentiation)
GO:0002741 (positive regulation of cytokine secretion involved in immune response)
GO:0006006 (glucose metabolic process)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006357 (regulation of transcription from RNA polymerase II promoter)
GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0006974 (cellular response to DNA damage stimulus)
GO:0007178 (transmembrane receptor protein serine/threonine kinase signaling pathway)
GO:0007519 (skeletal muscle tissue development)
GO:0010628 (positive regulation of gene expression)
GO:0010759 (positive regulation of macrophage chemotaxis)
GO:0010831 (positive regulation of myotube differentiation)
GO:0014835 (myoblast differentiation involved in skeletal muscle regeneration)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0019395 (fatty acid oxidation)
GO:0030278 (regulation of ossification)
GO:0030316 (osteoclast differentiation)
GO:0031281 (positive regulation of cyclase activity)
GO:0031663 (lipopolysaccharide-mediated signaling pathway)
GO:0032495 (response to muramyl dipeptide)
GO:0032496 (response to lipopolysaccharide)
GO:0035556 (intracellular signal transduction)
GO:0035924 (cellular response to vascular endothelial growth factor stimulus)
GO:0035994 (response to muscle stretch)
GO:0038066 (p38MAPK cascade)
GO:0042307 (positive regulation of protein import into nucleus)
GO:0042770 (signal transduction in response to DNA damage)
GO:0045648 (positive regulation of erythrocyte differentiation)
GO:0045663 (positive regulation of myoblast differentiation)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046326 (positive regulation of glucose import)
GO:0046777 (protein autophosphorylation)
GO:0048010 (vascular endothelial growth factor receptor signaling pathway)
GO:0051146 (striated muscle cell differentiation)
GO:0051403 (stress-activated MAPK cascade)
GO:0060045 (positive regulation of cardiac muscle cell proliferation)
GO:0071222 (cellular response to lipopolysaccharide)
GO:0071223 (cellular response to lipoteichoic acid)
GO:0071356 (cellular response to tumor necrosis factor)
GO:0071479 (cellular response to ionizing radiation)
GO:0090090 (negative regulation of canonical Wnt signaling pathway)
GO:0090336 (positive regulation of brown fat cell differentiation)
GO:0090400 (stress-induced premature senescence)
GO:0098586 (cellular response to virus)
GO:1900015 (regulation of cytokine production involved in inflammatory response)
GO:1901741 (positive regulation of myoblast fusion)
GO:1905050 (positive regulation of metallopeptidase activity)
GO:2000379 (positive regulation of reactive oxygen species metabolic process)
GO:2001184 (positive regulation of interleukin-12 secretion)

Target Cross References - Protein

canSAR P47811
IntAct P47811
Reactome R-MMU-168638 (NOD1/2 Signaling Pathway.)
R-MMU-171007 (p38MAPK events.)
R-MMU-198753 (ERK/MAPK targets.)
R-MMU-2559580 (Oxidative Stress Induced Senescence.)
R-MMU-375170 (CDO in myogenesis.)
R-MMU-376172 (DSCAM interactions.)
R-MMU-418592 (ADP signalling through P2Y purinoceptor 1.)
R-MMU-432142 (Platelet sensitization by LDL.)
R-MMU-4420097 (VEGFA-VEGFR2 Pathway.)
R-MMU-450302 (activated TAK1 mediates p38 MAPK activation.)
R-MMU-450341 (Activation of the AP-1 family of transcription factors.)
R-MMU-6798695 (Neutrophil degranulation.)
R-MMU-6804756 (Regulation of TP53 Activity through Phosphorylation.)
UniProt B2KF37 B2KF38 O08666 P47811 Q3U6R5 Q3UZS3 Q8C289 Q9JLV8 Q9QZ80

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR003527 (MAP_kinase_CS.)
IPR008352 (MAPK_p38.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 1LEW 1LEZ 1YW2 1YWR 2EWA 2GHL 2GHM 2GTM 2GTN 2OZA 2PUU 3P4K 3P5K 3P78 3P79 3P7A 3P7B 3P7C 3PY3 3TG1 4KA3 4LOO 4LOP 4LOQ More...
CREDO 1LEW 1LEZ 1YW2 1YWR 2EWA 2GHL 2GHM 2GTM 2GTN 2OZA 2PUU 3P4K 3P5K 3P78 3P79 3P7A 3P7B 3P7C 3PY3 3TG1 4KA3 4LOO 4LOP 4LOQ More...