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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2335
Target Type SINGLE PROTEIN
Preferred Name Lysosomal Pro-X carboxypeptidase
Synonyms Angiotensinase C | Lysosomal Pro-X carboxypeptidase | Lysosomal carboxypeptidase C | PCP | PRCP | PRCP | Proline carboxypeptidase | Prolylcarboxypeptidase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > serine protease > serine protease sc clan > serine protease s28 family

Target Components

Component Description Relationship Accession
Lysosomal Pro-X carboxypeptidase SINGLE PROTEIN P42785

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000137509
Ensembl ENSG00000137509
GO Cellular Component GO:0005764 (lysosome)
GO:0005886 (plasma membrane)
GO:0035577 (azurophil granule membrane)
GO:0045178 (basal part of cell)
GO:0070062 (extracellular exosome)
GO:0101003 (ficolin-1-rich granule membrane)
GO Molecular Function GO:0004180 (carboxypeptidase activity)
GO:0004185 (serine-type carboxypeptidase activity)
GO:0005515 (protein binding)
GO:0008233 (peptidase activity)
GO:0008236 (serine-type peptidase activity)
GO:0008239 (dipeptidyl-peptidase activity)
GO:0016787 (hydrolase activity)
GO Biological Process GO:0002155 (regulation of thyroid hormone mediated signaling pathway)
GO:0002353 (plasma kallikrein-kinin cascade)
GO:0003085 (negative regulation of systemic arterial blood pressure)
GO:0006508 (proteolysis)
GO:0007597 (blood coagulation, intrinsic pathway)
GO:0042593 (glucose homeostasis)
GO:0043312 (neutrophil degranulation)
GO:0043535 (regulation of blood vessel endothelial cell migration)
GO:0060055 (angiogenesis involved in wound healing)
GO:0097009 (energy homeostasis)
GO:2000377 (regulation of reactive oxygen species metabolic process)
Wikipedia PRCP

Target Cross References - Protein

canSAR P42785
Human Protein Atlas ENSG00000137509
IntAct P42785
Guide to Pharmacology 1584
Open Targets ENSG00000137509
PharmGKB PA33705
Reactome R-HSA-140837 (Intrinsic Pathway of Fibrin Clot Formation.)
R-HSA-6798695 (Neutrophil degranulation.)
UniProt A8MU24 B2R7B7 B3KRK5 B5BU34 P42785

Target Cross References - Domain

InterPro IPR008758 (Peptidase_S28.)
IPR029058 (AB_hydrolase.)
Pfam PF05577 (Peptidase_S28)

Target Cross References - Structure

PDBe 3N2Z
CREDO 3N2Z
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