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Target Report Card

Target Name and Classification

Target ID CHEMBL2321640
Target Type SINGLE PROTEIN
Preferred Name Frataxin, mitochondrial
Synonyms FRDA | FXN | Frataxin intermediate form | Frataxin mature form | Frataxin(56-210) | Frataxin(78-210) | Frataxin(81-210) | Frataxin, mitochondrial | Friedreich ataxia protein | Fxn | X25 | d-FXN | i-FXN | m56-FXN | m78-FXN | m81-FXN
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Frataxin, mitochondrial SINGLE PROTEIN Q16595

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000165060
Ensembl ENSG00000165060
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005759 (mitochondrial matrix)
GO:0005829 (cytosol)
GO Molecular Function GO:0004322 (ferroxidase activity)
GO:0005515 (protein binding)
GO:0008198 (ferrous iron binding)
GO:0008199 (ferric iron binding)
GO:0016491 (oxidoreductase activity)
GO:0034986 (iron chaperone activity)
GO:0046872 (metal ion binding)
GO:0051537 (2 iron, 2 sulfur cluster binding)
GO Biological Process GO:0006783 (heme biosynthetic process)
GO:0006811 (ion transport)
GO:0006879 (cellular iron ion homeostasis)
GO:0008284 (positive regulation of cell proliferation)
GO:0010039 (response to iron ion)
GO:0010722 (regulation of ferrochelatase activity)
GO:0016226 (iron-sulfur cluster assembly)
GO:0016540 (protein autoprocessing)
GO:0018283 (iron incorporation into metallo-sulfur cluster)
GO:0030307 (positive regulation of cell growth)
GO:0043066 (negative regulation of apoptotic process)
GO:0043085 (positive regulation of catalytic activity)
GO:0044281 (small molecule metabolic process)
GO:0051349 (positive regulation of lyase activity)
GO:0055072 (iron ion homeostasis)
GO:0055114 (oxidation-reduction process)
GO:0070301 (cellular response to hydrogen peroxide)
GO:0090201 (negative regulation of release of cytochrome c from mitochondria)
GO:1904231 (positive regulation of succinate dehydrogenase activity)
GO:1904234 (positive regulation of aconitate hydratase activity)

Target Cross References - Protein

Human Protein Atlas ENSG00000165060
IntAct Q16595
Open Targets ENSG00000165060
Reactome R-HSA-1268020 (Mitochondrial protein import.)
R-HSA-1362409 (Mitochondrial iron-sulfur cluster biogenesis.)
UniProt A8MXJ6 C9JJ89 O15545 O95656 Q15294 Q16595 Q5VZ01

Target Cross References - Domain

InterPro IPR002908 (Frataxin/CyaY.)
IPR017789 (Frataxin.)
IPR020895 (Frataxin_CS.)
IPR036524 (Frataxin/CyaY_sf.)
Pfam PF01491 (Frataxin_Cyay)

Target Cross References - Structure

PDBe 1EKG 3S4M 3S5D 3S5E 3S5F 3T3J 3T3K 3T3L 3T3T 3T3X
CREDO 1EKG 3S4M 3S5D 3S5E 3S5F 3T3J 3T3K 3T3L 3T3T 3T3X
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