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ChEMBL

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Target Report Card

Target Name and Classification

Target ID CHEMBL2311228
Target Type SINGLE PROTEIN
Preferred Name Cell division control protein 6 homolog
Synonyms CDC18L | CDC6 | CDC6-related protein | Cdc18-related protein | Cell division control protein 6 homolog | HsCDC6 | HsCdc18 | p62(cdc6)
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Cell division control protein 6 homolog SINGLE PROTEIN Q99741

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000094804
Ensembl ENSG00000094804
GO Cellular Component GO:0000922 (spindle pole)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005794 (Golgi apparatus)
GO:0005829 (cytosol)
GO:0051233 (spindle midzone)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0019900 (kinase binding)
GO Biological Process GO:0000076 (DNA replication checkpoint)
GO:0000079 (regulation of cyclin-dependent protein serine/threonine kinase activity)
GO:0000082 (G1/S transition of mitotic cell cycle)
GO:0000083 (regulation of transcription involved in G1/S transition of mitotic cell cycle)
GO:0006260 (DNA replication)
GO:0006270 (DNA replication initiation)
GO:0007049 (cell cycle)
GO:0007067 (mitotic nuclear division)
GO:0007089 (traversing start control point of mitotic cell cycle)
GO:0008156 (negative regulation of DNA replication)
GO:0008285 (negative regulation of cell proliferation)
GO:0030071 (regulation of mitotic metaphase/anaphase transition)
GO:0032467 (positive regulation of cytokinesis)
GO:0045737 (positive regulation of cyclin-dependent protein serine/threonine kinase activity)
GO:0048146 (positive regulation of fibroblast proliferation)
GO:0051301 (cell division)
GO:0051984 (positive regulation of chromosome segregation)
GO:1904117 (cellular response to vasopressin)
GO:1904385 (cellular response to angiotensin)

Target Cross References - Protein

Human Protein Atlas ENSG00000094804
IntAct Q99741
Open Targets ENSG00000094804
Reactome R-HSA-113510 (E2F mediated regulation of DNA replication.)
R-HSA-1538133 (G0 and Early G1.)
R-HSA-176187 (Activation of ATR in response to replication stress.)
R-HSA-68689 (CDC6 association with the ORC:origin complex.)
R-HSA-68827 (CDT1 association with the CDC6:ORC:origin complex.)
R-HSA-68867 (Assembly of the pre-replicative complex.)
R-HSA-68949 (Orc1 removal from chromatin.)
R-HSA-68962 (Activation of the pre-replicative complex.)
R-HSA-69017 (CDK-mediated phosphorylation and removal of Cdc6.)
R-HSA-69205 (G1/S-Specific Transcription.)
R-HSA-69298 (Association of licensing factors with the pre-replicative complex.)
R-HSA-69300 (Removal of licensing factors from origins.)
UniProt Q8TB30 Q99741

Target Cross References - Domain

InterPro IPR003593 (AAA+_ATPase.)
IPR011991 (WHTH_DNA-bd_dom.)
IPR015163 (Cdc6_C.)
IPR016314 (Cdc6/18.)
IPR027417 (P-loop_NTPase.)
Pfam PF09079 (Cdc6_C)
PF13401 (AAA_22)

Target Cross References - Structure

PDBe 2CCH 2CCI 4I5L 4I5N
CREDO 2CCH 2CCI 4I5L 4I5N
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