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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2311
Target Type SINGLE PROTEIN
Preferred Name Angiotensin-converting enzyme-related carboxypeptidase
Synonyms ACE-related carboxypeptidase | Ace2 | Angiotensin-converting enzyme 2 | Processed angiotensin-converting enzyme 2
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mae clan > metallo protease m2 family

Target Components

Component Description Relationship Accession
Angiotensin-converting enzyme 2 SINGLE PROTEIN Q5EGZ1

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0001618 (virus receptor activity)
GO:0004180 (carboxypeptidase activity)
GO:0008233 (peptidase activity)
GO:0008237 (metallopeptidase activity)
GO:0008241 (peptidyl-dipeptidase activity)
GO:0016787 (hydrolase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006508 (proteolysis)
GO:0046718 (viral entry into host cell)
GO:0048662 (negative regulation of smooth muscle cell proliferation)
GO:0060135 (maternal process involved in female pregnancy)
GO:0070373 (negative regulation of ERK1 and ERK2 cascade)

Target Cross References - Protein

canSAR Q5EGZ1
UniProt Q5EGZ1

Target Cross References - Domain

InterPro IPR001548 (Peptidase_M2.)
IPR031588 (Collectrin_dom.)
IPR033591 (ACE2.)
Pfam PF01401 (Peptidase_M2)
PF16959 (Collectrin)
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