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Target Report Card

Target Name and Classification

Target ID CHEMBL230
Preferred Name Cyclooxygenase-2
Synonyms COX-2 | COX2 | Cyclooxygenase-2 | PGH synthase 2 | PGHS-2 | PHS II | PTGS2 | Prostaglandin G/H synthase 2 | Prostaglandin H2 synthase 2 | Prostaglandin-endoperoxide synthase 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > oxidoreductase

Target Components

Component Description Relationship Accession
Prostaglandin G/H synthase 2 SINGLE PROTEIN P35354

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094253 Cyclooxygenase PROTEIN FAMILY
CHEMBL3885623 Prostaglandin E synthase/G/H synthase 2 PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL416146 ETORICOXIB Cyclooxygenase-2 inhibitor 4 PubMed
CHEMBL118 CELECOXIB Cyclooxygenase-2 inhibitor 4 DailyMed
CHEMBL599 MELOXICAM Cyclooxygenase-2 inhibitor 4 PubMed
CHEMBL122 ROFECOXIB Cyclooxygenase-2 inhibitor 4 FDA
CHEMBL622 ETODOLAC Cyclooxygenase-2 inhibitor 4 PubMed
CHEMBL865 VALDECOXIB Cyclooxygenase-2 inhibitor 4 DailyMed
CHEMBL296913 PARECOXIB SODIUM Cyclooxygenase-2 inhibitor 4 PubChem PubMed
CHEMBL1070 NABUMETONE Cyclooxygenase-2 inhibitor 4 DailyMed
CHEMBL93645 ACECLOFENAC Cyclooxygenase-2 inhibitor 4 Other PubMed PubMed PubMed
CHEMBL1316 CARPROFEN Cyclooxygenase-2 inhibitor 4 DailyMed
CHEMBL404108 LUMIRACOXIB Cyclooxygenase-2 inhibitor 4 PubMed PubMed PubMed
CHEMBL1206690 PARECOXIB Cyclooxygenase-2 inhibitor 4 PubMed PubMed PubMed PubMed
CHEMBL166863 POLMACOXIB Cyclooxygenase-2 inhibitor 3 PubMed PubMed
CHEMBL1835207 APRICOXIB Cyclooxygenase-2 inhibitor 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000073756
Ensembl ENSG00000073756
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005783 (endoplasmic reticulum)
GO:0005788 (endoplasmic reticulum lumen)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005901 (caveola)
GO:0016020 (membrane)
GO:0031090 (organelle membrane)
GO:0032991 (macromolecular complex)
GO:0043005 (neuron projection)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0004601 (peroxidase activity)
GO:0004666 (prostaglandin-endoperoxide synthase activity)
GO:0005515 (protein binding)
GO:0016491 (oxidoreductase activity)
GO:0016702 (oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)
GO:0019899 (enzyme binding)
GO:0020037 (heme binding)
GO:0042803 (protein homodimerization activity)
GO:0046872 (metal ion binding)
GO:0050473 (arachidonate 15-lipoxygenase activity)
GO:0051213 (dioxygenase activity)
GO Biological Process GO:0001516 (prostaglandin biosynthetic process)
GO:0001525 (angiogenesis)
GO:0006629 (lipid metabolic process)
GO:0006631 (fatty acid metabolic process)
GO:0006633 (fatty acid biosynthetic process)
GO:0006693 (prostaglandin metabolic process)
GO:0006954 (inflammatory response)
GO:0006979 (response to oxidative stress)
GO:0007566 (embryo implantation)
GO:0007568 (aging)
GO:0007612 (learning)
GO:0007613 (memory)
GO:0008217 (regulation of blood pressure)
GO:0008284 (positive regulation of cell proliferation)
GO:0008285 (negative regulation of cell proliferation)
GO:0009314 (response to radiation)
GO:0009750 (response to fructose)
GO:0010033 (response to organic substance)
GO:0010042 (response to manganese ion)
GO:0010226 (response to lithium ion)
GO:0010243 (response to organonitrogen compound)
GO:0010575 (positive regulation of vascular endothelial growth factor production)
GO:0010942 (positive regulation of cell death)
GO:0014070 (response to organic cyclic compound)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0019233 (sensory perception of pain)
GO:0019371 (cyclooxygenase pathway)
GO:0019372 (lipoxygenase pathway)
GO:0030282 (bone mineralization)
GO:0030728 (ovulation)
GO:0031394 (positive regulation of prostaglandin biosynthetic process)
GO:0031622 (positive regulation of fever generation)
GO:0031915 (positive regulation of synaptic plasticity)
GO:0032227 (negative regulation of synaptic transmission, dopaminergic)
GO:0032355 (response to estradiol)
GO:0032496 (response to lipopolysaccharide)
GO:0033138 (positive regulation of peptidyl-serine phosphorylation)
GO:0033280 (response to vitamin D)
GO:0034097 (response to cytokine)
GO:0034356 (NAD biosynthesis via nicotinamide riboside salvage pathway)
GO:0034605 (cellular response to heat)
GO:0034612 (response to tumor necrosis factor)
GO:0034644 (cellular response to UV)
GO:0035633 (maintenance of blood-brain barrier)
GO:0042127 (regulation of cell proliferation)
GO:0042307 (positive regulation of protein import into nucleus)
GO:0042493 (response to drug)
GO:0042633 (hair cycle)
GO:0043065 (positive regulation of apoptotic process)
GO:0043066 (negative regulation of apoptotic process)
GO:0043154 (negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0045429 (positive regulation of nitric oxide biosynthetic process)
GO:0045786 (negative regulation of cell cycle)
GO:0045907 (positive regulation of vasoconstriction)
GO:0045986 (negative regulation of smooth muscle contraction)
GO:0045987 (positive regulation of smooth muscle contraction)
GO:0046697 (decidualization)
GO:0048661 (positive regulation of smooth muscle cell proliferation)
GO:0050727 (regulation of inflammatory response)
GO:0050873 (brown fat cell differentiation)
GO:0051384 (response to glucocorticoid)
GO:0051926 (negative regulation of calcium ion transport)
GO:0051968 (positive regulation of synaptic transmission, glutamatergic)
GO:0055114 (oxidation-reduction process)
GO:0070542 (response to fatty acid)
GO:0071260 (cellular response to mechanical stimulus)
GO:0071284 (cellular response to lead ion)
GO:0071318 (cellular response to ATP)
GO:0071456 (cellular response to hypoxia)
GO:0071471 (cellular response to non-ionic osmotic stress)
GO:0071498 (cellular response to fluid shear stress)
GO:0071636 (positive regulation of transforming growth factor beta production)
GO:0090050 (positive regulation of cell migration involved in sprouting angiogenesis)
GO:0090271 (positive regulation of fibroblast growth factor production)
GO:0090336 (positive regulation of brown fat cell differentiation)
GO:0090362 (positive regulation of platelet-derived growth factor production)
GO:0097756 (negative regulation of blood vessel diameter)
GO:0098869 (cellular oxidant detoxification)
GO:1902219 (negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress)
GO:1990776 (response to angiotensin)
Wikipedia Prostaglandin-endoperoxide_synthase_2

Target Cross References - Protein

canSAR P35354
Human Protein Atlas ENSG00000073756
IntAct P35354
Guide to Pharmacology 1376
Open Targets ENSG00000073756
PharmGKB PA293
Reactome R-HSA-197264 (Nicotinamide salvaging.)
R-HSA-2142770 (Synthesis of 15-eicosatetraenoic acid derivatives.)
R-HSA-2162123 (Synthesis of Prostaglandins (PG) and Thromboxanes (TX).)
R-HSA-6783783 (Interleukin-10 signaling.)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
UniProt A8K802 P35354 Q16876

Target Cross References - Domain

InterPro IPR000742 (EGF-like_dom.)
IPR010255 (Haem_peroxidase.)
IPR019791 (Haem_peroxidase_animal.)
IPR029576 (COX-2.)
IPR037120 (Haem_peroxidase_sf.)
Pfam PF00008 (EGF)
PF03098 (An_peroxidase)

Target Cross References - Structure