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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2289
Target Type SINGLE PROTEIN
Preferred Name Beta-2 adrenergic receptor
Synonyms ADRB2 | Beta-2 adrenergic receptor | Beta-2 adrenoceptor | Beta-2 adrenoreceptor
Organism Canis lupus familiaris
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > adrenergic receptor

Target Components

Component Description Relationship Accession
Beta-2 adrenergic receptor SINGLE PROTEIN P54833

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005768 (endosome)
GO:0005769 (early endosome)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043235 (receptor complex)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004935 (adrenergic receptor activity)
GO:0004941 (beta2-adrenergic receptor activity)
GO:0042803 (protein homodimerization activity)
GO:0051379 (epinephrine binding)
GO:0051380 (norepinephrine binding)
GO Biological Process GO:0002025 (vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure)
GO:0002032 (desensitization of G-protein coupled receptor protein signaling pathway by arrestin)
GO:0006898 (receptor-mediated endocytosis)
GO:0006940 (regulation of smooth muscle contraction)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007189 (adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:0007190 (activation of adenylate cyclase activity)
GO:0007267 (cell-cell signaling)
GO:0042312 (regulation of vasodilation)
GO:0043410 (positive regulation of MAPK cascade)
GO:0045986 (negative regulation of smooth muscle contraction)
GO:0071880 (adenylate cyclase-activating adrenergic receptor signaling pathway)
GO:1901098 (positive regulation of autophagosome maturation)
GO:1904504 (positive regulation of lipophagy)

Target Cross References - Protein

canSAR P54833
UniProt P54833

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000332 (ADRB2_rcpt.)
IPR002233 (ADR_fam.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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