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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2281
Target Type SINGLE PROTEIN
Preferred Name Dopamine D5 receptor
Synonyms D(1B) dopamine receptor | D(5) dopamine receptor | Dopamine D5 receptor | Drd5
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > dopamine receptor

Target Components

Component Description Relationship Accession
D(1B) dopamine receptor SINGLE PROTEIN P25115

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2093868 Dopamine receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005622 (intracellular)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0031526 (brush border membrane)
GO:0043025 (neuronal cell body)
GO:0043197 (dendritic spine)
GO Molecular Function GO:0001588 (dopamine neurotransmitter receptor activity, coupled via Gs)
GO:0001965 (G-protein alpha-subunit binding)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004952 (dopamine neurotransmitter receptor activity)
GO:0005515 (protein binding)
GO:0008144 (drug binding)
GO Biological Process GO:0001963 (synaptic transmission, dopaminergic)
GO:0006469 (negative regulation of protein kinase activity)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007189 (adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:0007191 (adenylate cyclase-activating dopamine receptor signaling pathway)
GO:0007212 (dopamine receptor signaling pathway)
GO:0008542 (visual learning)
GO:0030336 (negative regulation of cell migration)
GO:0048169 (regulation of long-term neuronal synaptic plasticity)
GO:0060158 (phospholipase C-activating dopamine receptor signaling pathway)

Target Cross References - Protein

canSAR P25115
UniProt P25115

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000497 (Dopamine_D5_rcpt.)
IPR000929 (Dopamine_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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