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Target Report Card

Target Name and Classification

Target ID CHEMBL2276
Preferred Name c-Jun N-terminal kinase 1
Synonyms JNK-46 | JNK1 | MAP kinase 8 | MAPK 8 | MAPK8 | Mitogen-activated protein kinase 8 | PRKM8 | SAPK1 | SAPK1C | SAPK1c | Stress-activated protein kinase 1c | Stress-activated protein kinase JNK1 | c-Jun N-terminal kinase 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > cmgc protein kinase group > cmgc protein kinase mapk family > cmgc protein kinase jnk subfamily

Target Components

Component Description Relationship Accession
Mitogen-activated protein kinase 8 SINGLE PROTEIN P45983

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096667 c-Jun N-terminal kinase, JNK PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1614713 CC-401 c-Jun N-terminal kinase 1 inhibitor 2 Other PubMed
CHEMBL1950289 TANZISERTIB c-Jun N-terminal kinase 1 inhibitor 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000107643
Ensembl ENSG00000107643
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005829 (cytosol)
GO:0030424 (axon)
GO:0043005 (neuron projection)
GO:0097441 (basilar dendrite)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004705 (JUN kinase activity)
GO:0004707 (MAP kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019899 (enzyme binding)
GO:0035033 (histone deacetylase regulator activity)
GO:0042826 (histone deacetylase binding)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0007254 (JNK cascade)
GO:0007258 (JUN phosphorylation)
GO:0009411 (response to UV)
GO:0010628 (positive regulation of gene expression)
GO:0016241 (regulation of macroautophagy)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0018107 (peptidyl-threonine phosphorylation)
GO:0031063 (regulation of histone deacetylation)
GO:0031281 (positive regulation of cyclase activity)
GO:0032091 (negative regulation of protein binding)
GO:0032880 (regulation of protein localization)
GO:0034198 (cellular response to amino acid starvation)
GO:0034614 (cellular response to reactive oxygen species)
GO:0038095 (Fc-epsilon receptor signaling pathway)
GO:0042752 (regulation of circadian rhythm)
GO:0043065 (positive regulation of apoptotic process)
GO:0043066 (negative regulation of apoptotic process)
GO:0048511 (rhythmic process)
GO:0048666 (neuron development)
GO:0051090 (regulation of sequence-specific DNA binding transcription factor activity)
GO:0051247 (positive regulation of protein metabolic process)
GO:0051403 (stress-activated MAPK cascade)
GO:0071222 (cellular response to lipopolysaccharide)
GO:0071260 (cellular response to mechanical stimulus)
GO:0071276 (cellular response to cadmium ion)
GO:0071345 (cellular response to cytokine stimulus)
GO:0090045 (positive regulation of deacetylase activity)
GO:1900740 (positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)
GO:1902595 (regulation of DNA replication origin binding)
Wikipedia MAPK8

Target Cross References - Protein

canSAR P45983
Human Protein Atlas ENSG00000107643
IntAct P45983
Guide to Pharmacology 1496
Open Targets ENSG00000107643
PharmGKB PA283
Pharos P45983 (Tchem)
Reactome R-HSA-111446 (Activation of BIM and translocation to mitochondria.)
R-HSA-139910 (Activation of BMF and translocation to mitochondria.)
R-HSA-193648 (NRAGE signals death through JNK.)
R-HSA-205043 (NRIF signals cell death from the nucleus.)
R-HSA-2559580 (Oxidative Stress Induced Senescence.)
R-HSA-2871796 (FCERI mediated MAPK activation.)
R-HSA-376172 (DSCAM interactions.)
R-HSA-450321 (JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.)
R-HSA-450341 (Activation of the AP-1 family of transcription factors.)
R-HSA-5693565 (Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.)
R-HSA-9007892 (Interleukin-38 signaling.)
UniProt B5BTZ5 B7ZLV4 D3DX88 D3DX92 P45983 Q15709 Q15712 Q15713 Q308M2

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR003527 (MAP_kinase_CS.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR008351 (MAPK_JNK.)
IPR011009 (Kinase-like_dom_sf.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 1UKH 1UKI 2G01 2GMX 2H96 2NO3 2XRW 2XS0 3ELJ 3O17 3O2M 3PZE 3V3V 3VUD 3VUG 3VUH 3VUI 3VUK 3VUL 3VUM 4AWI 4E73 4G1W 4HYS More...
CREDO 1UKH 1UKI 2G01 2GMX 2H96 2NO3 2XRW 2XS0 3ELJ 3O17 3O2M 3PZE 3V3V 3VUD 3VUG 3VUH 3VUI 3VUK 3VUL 3VUM 4AWI 4E73 4G1W 4HYS More...