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Target Report Card

Target Name and Classification

Target ID CHEMBL227
Target Type SINGLE PROTEIN
Preferred Name Type-1 angiotensin II receptor
Synonyms AGTR1 | AGTR1A | AGTR1B | AT1 | AT1AR | AT1BR | AT2R1 | AT2R1B | Angiotensin II type-1 receptor | Type-1 angiotensin II receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > short peptide receptor (family a gpcr) > angiotensin receptor

Target Components

Component Description Relationship Accession
Type-1 angiotensin II receptor SINGLE PROTEIN P30556

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094256 Angiotensin II receptor PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL995 LOSARTAN POTASSIUM Type-1 angiotensin II receptor antagonist 4 DailyMed
CHEMBL1014 CANDESARTAN CILEXETIL Type-1 angiotensin II receptor antagonist 4 DailyMed
CHEMBL1017 TELMISARTAN Type-1 angiotensin II receptor antagonist 4 DailyMed PubMed PubMed
CHEMBL1069 VALSARTAN Type-1 angiotensin II receptor antagonist 4 DailyMed FDA
CHEMBL1513 IRBESARTAN Type-1 angiotensin II receptor antagonist 4 DailyMed FDA
CHEMBL1200670 SARALASIN ACETATE Type-1 angiotensin II receptor antagonist 4 PubMed
CHEMBL1200692 OLMESARTAN MEDOXOMIL Type-1 angiotensin II receptor antagonist 4 DailyMed
CHEMBL1200987 EPROSARTAN MESYLATE Type-1 angiotensin II receptor antagonist 4 DailyMed FDA
CHEMBL2103795 AZILSARTAN KAMEDOXOMIL Type-1 angiotensin II receptor antagonist 4 DailyMed
CHEMBL57242 AZILSARTAN Type-1 angiotensin II receptor antagonist 3 PubMed PubMed
CHEMBL1516 OLMESARTAN Type-1 angiotensin II receptor antagonist 3 PubMed
CHEMBL41194 PRATOSARTAN Type-1 angiotensin II receptor antagonist 2 DOI
CHEMBL539423 SPARSENTAN Type-1 angiotensin II receptor antagonist 2 Other Other PubMed
More...

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000144891
Ensembl ENSG00000144891
GO Cellular Component GO:0005622 (intracellular)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0001596 (angiotensin type I receptor activity)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004945 (angiotensin type II receptor activity)
GO:0005515 (protein binding)
GO:0031711 (bradykinin receptor binding)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0001558 (regulation of cell growth)
GO:0001822 (kidney development)
GO:0002018 (renin-angiotensin regulation of aldosterone production)
GO:0002034 (regulation of blood vessel size by renin-angiotensin)
GO:0003081 (regulation of systemic arterial blood pressure by renin-angiotensin)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007200 (phospholipase C-activating G-protein coupled receptor signaling pathway)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007266 (Rho protein signal transduction)
GO:0010744 (positive regulation of macrophage derived foam cell differentiation)
GO:0010873 (positive regulation of cholesterol esterification)
GO:0019229 (regulation of vasoconstriction)
GO:0019722 (calcium-mediated signaling)
GO:0032270 (positive regulation of cellular protein metabolic process)
GO:0032430 (positive regulation of phospholipase A2 activity)
GO:0033864 (positive regulation of NAD(P)H oxidase activity)
GO:0034374 (low-density lipoprotein particle remodeling)
GO:0035813 (regulation of renal sodium excretion)
GO:0038166 (angiotensin-activated signaling pathway)
GO:0042127 (regulation of cell proliferation)
GO:0042312 (regulation of vasodilation)
GO:0050727 (regulation of inflammatory response)
GO:0050729 (positive regulation of inflammatory response)
GO:0051482 (positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway)
GO:0060326 (cell chemotaxis)
GO:0086097 (phospholipase C-activating angiotensin-activated signaling pathway)
GO:2000379 (positive regulation of reactive oxygen species metabolic process)
Wikipedia Angiotensin_II_receptor_type_1

Target Cross References - Protein

canSAR P30556
CGD Renal tubular dysgenesis
Human Protein Atlas ENSG00000144891
IntAct P30556
Guide to Pharmacology 34
Open Targets ENSG00000144891
PharmGKB PA43
Pharos P30556 (Tclin)
Reactome R-HSA-375276 (Peptide ligand-binding receptors.)
R-HSA-416476 (G alpha (q) signalling events.)
R-HSA-8856825 (Cargo recognition for clathrin-mediated endocytosis.)
R-HSA-8856828 (Clathrin-mediated endocytosis.)
UniProt P30556 Q13725 Q8TBK4

Target Cross References - Domain

InterPro IPR000190 (ATII_AT1_rcpt.)
IPR000248 (ATII_rcpt.)
IPR000276 (GPCR_Rhodpsn.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)

Target Cross References - Structure

PDBe 4YAY 4ZUD
CREDO 4YAY 4ZUD
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