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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2266
Target Type SINGLE PROTEIN
Preferred Name Gamma-amino-N-butyrate transaminase
Synonyms (S)-3-amino-2-methylpropionate transaminase | 4-aminobutyrate aminotransferase, mitochondrial | ABAT | GABA aminotransferase | GABA transaminase | GABA-AT | GABA-T | GABAT | Gamma-amino-N-butyrate transaminase | L-AIBAT
Organism Sus scrofa
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
4-aminobutyrate aminotransferase, mitochondrial SINGLE PROTEIN P80147

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005739 (mitochondrion)
GO:0005759 (mitochondrial matrix)
GO:0005829 (cytosol)
GO:0032144 (4-aminobutyrate transaminase complex)
GO Molecular Function GO:0003824 (catalytic activity)
GO:0003867 (4-aminobutyrate transaminase activity)
GO:0008483 (transaminase activity)
GO:0016740 (transferase activity)
GO:0030170 (pyridoxal phosphate binding)
GO:0032145 (succinate-semialdehyde dehydrogenase binding)
GO:0034386 (4-aminobutyrate:2-oxoglutarate transaminase activity)
GO:0042803 (protein homodimerization activity)
GO:0046872 (metal ion binding)
GO:0047298 ((S)-3-amino-2-methylpropionate transaminase activity)
GO:0051536 (iron-sulfur cluster binding)
GO:0051537 (2 iron, 2 sulfur cluster binding)
GO Biological Process GO:0009448 (gamma-aminobutyric acid metabolic process)
GO:0009450 (gamma-aminobutyric acid catabolic process)
GO:0042135 (neurotransmitter catabolic process)
GO:0048148 (behavioral response to cocaine)

Target Cross References - Protein

canSAR P80147
Reactome R-SSC-916853 (Degradation of GABA.)
UniProt P27820 P80147

Target Cross References - Domain

InterPro IPR004631 (4NH2But_aminotransferase_euk.)
IPR005814 (Aminotrans_3.)
IPR015421 (PyrdxlP-dep_Trfase_major.)
IPR015422 (PyrdxlP-dep_Trfase_dom1.)
IPR015424 (PyrdxlP-dep_Trfase.)
Pfam PF00202 (Aminotran_3)

Target Cross References - Structure

PDBe 1OHV 1OHW 1OHY 4Y0D 4Y0H 4Y0I 4ZSW 4ZSY
CREDO 1OHV 1OHW 1OHY 4Y0D 4Y0H 4Y0I 4ZSW 4ZSY
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